Topical and transdermal nanomedicines for cancer therapy
Topical and transdermal nanomedicine systems have attracted considerable attention in
anticancer therapy. The administration route toward the skin can transport active drugs …
anticancer therapy. The administration route toward the skin can transport active drugs …
Encapsulation: Controlled drug delivery
Pharmaceutical researchers have been utilizing biomaterials over the last 40 years to
develop controlled drug delivery systems (DDSs). The reason for the extensive …
develop controlled drug delivery systems (DDSs). The reason for the extensive …
Efficient delivery of signal-responsive gene carriers for disease-specific gene expression via bubble liposomes and sonoporation
A Tsuchiya, JH Kang, T Mori, Y Naritomi… - Colloids and Surfaces B …, 2017 - Elsevier
Sonoporation is a promising method to intracellularly deliver synthetic gene carriers that
have lower endocytotic uptake than viral carriers. Here, we applied sonoporation to deliver …
have lower endocytotic uptake than viral carriers. Here, we applied sonoporation to deliver …
Stabilization of cancer-specific gene carrier via hydrophobic interaction for a clear-cut response to cancer signaling
Here, we developed a new gene carrier, comprising a linear polyethylenimine (LPEI) grafted
with a hydrophobically modified cationic peptide containing a long alkyl chain, for use in …
with a hydrophobically modified cationic peptide containing a long alkyl chain, for use in …
Protein kinase Cα‐responsive polymeric carrier: its application for gene delivery into human cancers
For cancer‐targeting gene delivery, we applied a protein kinase C (PKC) α‐responsive
polymeric carrier to human cancers (U‐87 MG [human glioblastoma‐astrocytoma, epithelial …
polymeric carrier to human cancers (U‐87 MG [human glioblastoma‐astrocytoma, epithelial …
Transgene regulation system responding to Rho associated coiled-coil kinase (ROCK) activation
Recently, we have proposed a new system of gene regulation called 'drug or gene delivery
system responding to cellular signals'(D-RECS). In this system, transgene expression is …
system responding to cellular signals'(D-RECS). In this system, transgene expression is …
Stimuli-responsive polymers providing new opportunities for various applications
Uyaranlara duyarlı polimerler, çevrelerindeki koşullarda küçük bir değişiklik olduğunda
fiziksel veya kimyasal özelliklerini önemli ölçüde değiştirir. Koşullardaki değişikliklere bağlı …
fiziksel veya kimyasal özelliklerini önemli ölçüde değiştirir. Koşullardaki değişikliklere bağlı …
Enzyme-responsive and enzyme immobilized nanoplatforms for therapeutic delivery: An overview of research innovations and biomedical applications
Enzymes facilitate physiological function but are dysregulated in disease-associated
environments. The utilization of the altered enzyme activity for therapeutics exhibits …
environments. The utilization of the altered enzyme activity for therapeutics exhibits …
Effect of introduction of chondroitin sulfate into polymer-peptide conjugate responding to intracellular signals
We recently developed a novel tumor-targeted gene delivery system responding to
hyperactivated intracellular signals. Polymeric carrier for gene delivery consists of …
hyperactivated intracellular signals. Polymeric carrier for gene delivery consists of …
Improvement in the colloidal stability of protein kinase‐responsive polyplexes by PEG modification
A Tsuchiya, Y Naritomi, S Kushio… - … Research Part A, 2012 - Wiley Online Library
We have reported a disease‐cell specific gene expression system that is responsive to
intracellular signaling proteins (eg, protein kinases and proteases) hyperactivated in …
intracellular signaling proteins (eg, protein kinases and proteases) hyperactivated in …