Pathophysiology of myocardial infarction

NG Frangogiannis - Comprehensive Physiology, 2011 - Wiley Online Library
Myocardial infarction is defined as sudden ischemic death of myocardial tissue. In the
clinical context, myocardial infarction is usually due to thrombotic occlusion of a coronary …

The immune system and cardiac repair

NG Frangogiannis - Pharmacological research, 2008 - Elsevier
Myocardial infarction is the most common cause of cardiac injury and results in acute loss of
a large number of myocardial cells. Because the heart has negligible regenerative capacity …

Impact of COVID-19 on ST-segment elevation myocardial infarction care. The Spanish experience

O Rodríguez-Leor, B Cid-Álvarez, AP de Prado… - Revista Española de …, 2020 - Elsevier
Introduction and objectives The COVID-19 outbreak has had an unclear impact on the
treatment and outcomes of patients with ST-segment elevation myocardial infarction …

Guidelines for the diagnosis and treatment of chronic heart failure: executive summary (update 2005) The Task Force for the Diagnosis and Treatment of Chronic …

K Swedberg, J Cleland, H Dargie… - European heart …, 2005 - academic.oup.com
Guidelines and Expert Consensus Documents produced by Task Forces, expert groups, or
consensus panels. The chosen experts in these writing panels are asked to provide …

Left ventricular post-infarct remodeling: implications for systolic function improvement and outcomes in the modern era

P van der Bijl, R Abou, L Goedemans, BJ Gersh… - Heart Failure, 2020 - jacc.org
Objectives This study sought to investigate the impact of post-infarct left ventricular (LV)
remodeling on outcomes in the contemporary era. Background LV remodeling after ST …

[HTML][HTML] Fibroblasts in post-infarction inflammation and cardiac repair

W Chen, NG Frangogiannis - … et Biophysica Acta (BBA)-Molecular Cell …, 2013 - Elsevier
Fibroblasts are the predominant cell type in the cardiac interstitium. As the main matrix-
producing cells in the adult mammalian heart, fibroblasts maintain the integrity of the …

Infarct size by contrast enhanced cardiac magnetic resonance is a stronger predictor of outcomes than left ventricular ejection fraction or end-systolic volume index …

E Wu, JT Ortiz, P Tejedor, DC Lee, C Bucciarelli-Ducci… - Heart, 2008 - heart.bmj.com
Objectives: Ejection fraction (EF) and end-systolic volume index (ESVI) are established
predictors of outcomes following ST-segment elevation myocardial infarction (STEMI). We …

Heart failure and sudden death in patients with tachycardia-induced cardiomyopathy and recurrent tachycardia

P Nerheim, S Birger-Botkin, L Piracha, B Olshansky - Circulation, 2004 - Am Heart Assoc
Background—Tachycardia-induced cardiomyopathy is a reversible cause of heart failure.
We hypothesized that although left ventricular ejection fraction measurements normalize …

The mechanistic basis of infarct healing

NG Frangogiannis - Antioxidants & redox signaling, 2006 - liebertpub.com
Myocardial infarction triggers an inflammatory cascade that results in healing and
replacement of the damaged tissue with scar. Cardiomyocyte necrosis triggers innate …

Emerging roles of circRNAs in the pathological process of myocardial infarction

ZJ Wen, H Xin, YC Wang, HW Liu, YY Gao… - … Therapy-Nucleic Acids, 2021 - cell.com
Myocardial infarction (MI) is defined as cardiomyocyte death in a clinical context consistent
with ischemic insult. MI remains one of the leading causes of morbidity and mortality …