Acute leukemia characterized by chromosomal rearrangements requires additional
molecular disruptions to develop into full-blown malignancy,, yet the cooperative …

The origins of the adaptive immune system and the basis for its unique association with
vertebrate species have been a source of considerable speculation. In light of recent …

The genetic changes leading to the development of human cancer are accompanied by
alterations in the structure and modification status of chromatin, which represent powerful …

The mammalian adenosine monophosphate–activated protein kinase (AMPK) is a serine-
threonine kinase protein complex that is a central regulator of cellular energy homeostasis …

Within the last few years, knowledge about vitamins has increased dramatically. This new
edition of a bestseller presents comprehensive summaries that analyze the chemical …

The increasing number of individuals with comorbidities poses an urgent need to improve
the management of patients with multiple co-existing diseases. Among these comorbidities …

Reactive metabolites from carcinogens and oxidative stress can drive genetic mutations,
genomic instability, neoplastic transformation, and ultimately carcinogenesis. Numerous …

Dietary exposures can have consequences for health years or decades later and this raises
questions about the mechanisms through which such exposures are 'remembered'and how …

Methylation at DNA, RNA and protein levels plays critical roles in many cellular processes
and is associated with diverse differentiation events, physiological activities and human …

Chromatin reorganization is governed by multiple post-translational modifications of
chromosomal proteins and DNA,. These histone modifications are reversible, dynamic …