The activation of the tumor suppressor p53 facilitates the cellular response to genotoxic
stress; however, the p53 response can only be executed if its interaction with its inhibitor …

The study of cancer metabolism has evolved vastly beyond the remit of tumour proliferation
and survival with the identification of the role of 'oncometabolites' in tumorigenesis. Simply …

Histone lysine acetylation is well known for being important in the epigenetic regulation of
gene expression in eukaryotic cells. Recent studies have uncovered a plethora of acetylated …

The behavior of transcriptomes and epigenomes in hybrids of heterotic parents is of
fundamental interest. Here, we report highly integrated maps of the epigenome, mRNA, and …

Chromatin is of major relevance for gene expression, cell division, and differentiation. Here,
we determined the landscape of Arabidopsis thaliana chromatin states using 16 features …

Cell migration and invasion are critical parameters in the metastatic dissemination of cancer
cells and the formation of metastasis, the major cause of death in cancer patients. Migratory …

Various chemical modifications on histones and regions of associated DNA play crucial
roles in genome management by binding specific factors that, in turn, serve to alter the …

In their struggle for life, plants can employ sophisticated strategies to defend themselves
against potentially harmful pathogens and insects. One mechanism by which plants can …

Microtubules have important functions ranging from maintenance of cell morphology to
subcellular transport, cellular signaling, cell migration, and formation of cell polarity. At the …

Various independent discoveries have shown that many organic codes exist in living
systems, and this implies that they came into being during the history of life and contributed …