Acute lymphoblastic leukemia (ALL) is the malignancy with the highest incidence amongst
children (26% of all cancer cases), being surpassed only by the cancers of the brain and of …

Acute promyelocytic leukemia (APL) is one of the most life‐threatening hematological
malignancies. Defects in the cell growth and apoptotic pathways are responsible for both …

FLT3 is considered a potential target of acute myeloid leukemia therapy. In this study, we
applied a computer-aided methodology unifying molecular docking and pharmacophore …

The use of all‐trans retinoic acid (ATRA) has dramatically improved the treatment and
survival rate of patients with acute promyelocytic leukemia (APL). However, toxicity and …

Objective: Acute promyelocytic leukemia (APL) is among the most threatening hematological
malignant cancers. Defects in cell growth and apoptotic pathways lead to the pathogenesis …

Fms‐like tyrosine kinase 3 (FLT3) is a receptor tyrosine kinase that is a drug target for
leukemias. Several potent inhibitors of FLT3 exist, and bind to the inactive form of the …

Objective: Cuscuta campestris or common dodder is a holoparasitic plant that has been
valorized for treatment of liver injury and cancer prevention in traditional medicine. Recently …

Crocetin, the major carotenoid in saffron, exhibits potent anticancer effects. However, the
antileukemic effects of crocetin are still unclear, especially in primary acute promyelocytic …

Background As a major carotenoid in saffron, crocin demonstrates potent anti-cancer
impacts. However, its anti-lymphoma effects remain vague, especially in the human EBV …

A series of novel thiazolidine-4-one urea analogues were designed, synthesized and
biologically evaluated. The structure-activity relationship (SAR) at several positions of the …