Development of an NIH consortium for preclinicAl AssESsment of CARdioprotective therapies (CAESAR): a paradigm shift in studies of infarct size limitation

DJ Lefer, R Bolli - Journal of cardiovascular pharmacology …, 2011 - journals.sagepub.com
An estimated 935 000 Americans suffer a myocardial infarction every year; because their
prognosis is determined by the size of the infarct, reducing infarct size is of paramount …

Circumferential strain predicts major adverse cardiovascular events following an acute ST-segment–elevation myocardial infarction

K Mangion, D Carrick, J Carberry, A Mahrous… - Radiology, 2019 - pubs.rsna.org
Purpose To investigate the prognostic value of circumferential left ventricular (LV) strain
measured by using cardiac MRI for prediction of major adverse cardiac events (MACE) …

Aldosteronism and peripheral blood mononuclear cell activation: a neuroendocrine-immune interface

RA Ahokas, KJ Warrington, IC Gerling, Y Sun… - Circulation …, 2003 - Am Heart Assoc
Aldosteronism eventuates in a proinflammatory/fibrogenic vascular phenotype of the heart
and systemic organs. It remains uncertain whether peripheral blood mononuclear cells …

[HTML][HTML] Management of heart failure in patients with chronic kidney disease

DK Ryan, D Banerjee, F Jouhra - European Cardiology Review, 2022 - ncbi.nlm.nih.gov
Chronic kidney disease (CKD) is increasingly prevalent in patients with heart failure (HF)
and HF is one of the leading causes of hospitalisation, morbidity and mortality in patients …

Left ventricular myocardial work in the culprit vessel territory and impact on left ventricular remodelling in patients with ST-segment elevation myocardial infarction after …

RP Lustosa, F Fortuni, P van der Bijl… - European Heart …, 2021 - academic.oup.com
Aims Adverse left ventricular (LV) remodelling after ST-segment elevation myocardial
infarction (STEMI) is associated with poor outcome. Global and regional LV myocardial work …

Structural, functional, and molecular characterization of the SHHF model of heart failure

JRR Heyen, ER Blasi, K Nikula… - American Journal …, 2002 - journals.physiology.org
Heart failure is a complex multifactorial disease resulting in a myriad of progressive changes
at the molecular, cellular, and physiological level. To better understand the mechanisms …

Molecular imaging of early αvβ3 integrin expression predicts long-term left-ventricle remodeling after myocardial infarction in rats

HM Sherif, A Saraste, SG Nekolla, E Weidl… - Journal of Nuclear …, 2012 - Soc Nuclear Med
18F-galacto-RGD (18F-RGD) is a PET tracer binding to αvβ3 integrin receptors that are
upregulated after myocardial infarction (MI) as part of the healing process. We studied …

Loss of Nrf2 promotes rapid progression to heart failure following myocardial infarction

J Strom, QM Chen - Toxicology and applied pharmacology, 2017 - Elsevier
Nrf2 gene encodes a transcription factor regulating the expression of antioxidant and
detoxification genes. We test here whether Nrf2 plays a role for cardiac protection during …

Modern imaging techniques in cardiomyopathies

MF Jan, AJ Tajik - Circulation research, 2017 - Am Heart Assoc
Modern advanced imaging techniques have allowed increasingly more rigorous
assessment of the cardiac structure and function of several types of cardiomyopathies. In …

The use of cationic microbubbles to improve ultrasound-targeted gene delivery to the ischemic myocardium

L Sun, CW Huang, J Wu, KJ Chen, SH Li, RD Weisel… - Biomaterials, 2013 - Elsevier
We synthesized a cationic microbubble (CMB) with the aim of enhancing its DNA-carrying
capacity to improve targeted gene transfection of the ischemic heart for cardiac …