The tumor microenvironment (TME) is a complex meshwork of extracellular matrix (ECM)
macromolecules filled with a collection of cells including cancer-associated fibroblasts …

Collagen, an extracellular protein, covers the entire human body and has several important
biological functions in normal physiology. Recently, collagen from non-human sources has …

BACKGROUND The human uterine endometrium undergoes significant remodeling and
regeneration on a rapid and repeated basis, after parturition, menstruation, and in some …

ABSTRACT The α1β1, α2β1, α10β1 and α11β1 integrins constitute a subset of the integrin
family with affinity for GFOGER-like sequences in collagens. Integrins α1β1 and α2β1 were …

Cancers are complex ecosystems composed of malignant cells embedded in an intricate
microenvironment made of different non-transformed cell types and extracellular matrix …

Expansion of plastic-adherent bone marrow-derived mesenchymal stem cells (MSCs)
results in gradual loss of osteogenic potential after passage 5–6. One explanation is …

In the integrin family, the collagen receptors form a structurally and functionally distinct
subgroup. Two members of this subgroup, α 1 β 1 and α 2 β 1 integrins, are known to bind to …

Integrin α11β1 is a stromal cell-specific receptor for fibrillar collagens and is overexpressed
in carcinoma-associated fibroblasts (CAFs). We have investigated its direct role in cancer …

Polymerization of the ECM proteins fibronectin and laminin has been shown to take place in
close vicinity to the cell surface and be facilitated by β 1 integrins (Lohikangas, L., Gullberg …

Collagens are important platelet activators in the vascular subendothelium and vessel wall.
Since the regulation of platelet activation is a key step in distinguishing normal haemostasis …