The rapid rise of SARS‐CoV‐2 Omicron subvariants with immune evasion properties: XBB. 1.5 and BQ. 1.1 subvariants

D Ao, X He, W Hong, X Wei - MedComm, 2023 - Wiley Online Library
As the fifth variant of concern of the SARS‐CoV‐2 virus, the Omicron variant (B. 1.1. 529)
has quickly become the dominant type among the previous circulating variants worldwide …

Strategies for the development and approval of COVID-19 vaccines and therapeutics in the post-pandemic period

D Ao, X He, J Liu, L Xu - Signal Transduction and Targeted Therapy, 2023 - nature.com
The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted
in significant casualties and put immense strain on public health systems worldwide, leading …

Neutralization, effector function and immune imprinting of Omicron variants

A Addetia, L Piccoli, JB Case, YJ Park, M Beltramello… - Nature, 2023 - nature.com
Currently circulating SARS-CoV-2 variants have acquired convergent mutations at hot spots
in the receptor-binding domain (RBD) of the spike protein. The effects of these mutations on …

Distinct evolution of SARS-CoV-2 Omicron XBB and BA. 2.86/JN. 1 lineages combining increased fitness and antibody evasion

D Planas, I Staropoli, V Michel, F Lemoine… - Nature …, 2024 - nature.com
The unceasing circulation of SARS-CoV-2 leads to the continuous emergence of novel viral
sublineages. Here, we isolate and characterize XBB. 1, XBB. 1.5, XBB. 1.9. 1, XBB. 1.16. 1 …

TMPRSS2 is a functional receptor for human coronavirus HKU1

N Saunders, I Fernandez, C Planchais, V Michel… - Nature, 2023 - nature.com
Four endemic seasonal human coronaviruses causing common colds circulate worldwide:
HKU1, 229E, NL63 and OC43 (ref.). After binding to cellular receptors, coronavirus spike …

[HTML][HTML] Broadly neutralizing anti-S2 antibodies protect against all three human betacoronaviruses that cause deadly disease

P Zhou, G Song, H Liu, M Yuan, W He, N Beutler, X Zhu… - Immunity, 2023 - cell.com
Pan-betacoronavirus neutralizing antibodies may hold the key to developing broadly
protective vaccines against novel pandemic coronaviruses and to more effectively respond …

SARS-CoV-2 BA. 2.86 enters lung cells and evades neutralizing antibodies with high efficiency

L Zhang, A Kempf, I Nehlmeier, A Cossmann, A Richter… - Cell, 2024 - cell.com
Summary BA. 2.86, a recently identified descendant of the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) Omicron BA. 2 sublineage, contains∼ 35 mutations …

Duration of protection of ancestral-strain monovalent vaccines and effectiveness of bivalent BA. 1 boosters against COVID-19 hospitalisation in England: a test …

FCM Kirsebom, N Andrews, J Stowe… - The Lancet Infectious …, 2023 - thelancet.com
Background Bivalent BA. 1 booster vaccines were offered to adults aged 50 years or older
and clinically vulnerable people as part of the 2022 autumn COVID-19 booster vaccination …

Immune evasion of neutralizing antibodies by SARS-CoV-2 Omicron

L Wang, M Møhlenberg, P Wang, H Zhou - Cytokine & growth factor …, 2023 - Elsevier
Since its emergence at the end of 2019, severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) has caused the infection of more than 600 million people worldwide and has …

[HTML][HTML] Antigenic evolution of SARS coronavirus 2

AZ Mykytyn, RAM Fouchier, BL Haagmans - Current Opinion in Virology, 2023 - Elsevier
SARS coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, emerged in China in
December 2019. Vaccines developed were very effective initially, however, the virus has …