Effects of COMT polymorphisms on brain function and behavior in health and disease

AV Witte, A Flöel - Brain research bulletin, 2012 - Elsevier
The catechol-O-methyltransferase (COMT) gene has attracted strong neuroscientific interest
due to its implication in dopaminergic neurotransmission. One of its most widely studied …

Advances in molecular genetics of panic disorder

E Maron, JM Hettema, J Shlik - Molecular psychiatry, 2010 - nature.com
The molecular genetic research on panic disorder (PD) has grown tremendously in the past
decade. Although the data from twin and family studies suggest an involvement of genetic …

Intellectual interest mediates gene× socioeconomic status interaction on adolescent academic achievement

EM Tucker‐Drob, KP Harden - Child development, 2012 - Wiley Online Library
Recent studies have demonstrated that genetic influences on cognitive ability and academic
achievement are larger for children raised in higher socioeconomic status (SES) homes …

Genetics and learning: How the genes influence educational attainment

D Bueno - Frontiers in psychology, 2019 - frontiersin.org
The brain is the organ of thought. The word thought is defined as the act of thinking about or
considering something: an idea or opinion, or a set of ideas about a particular subject. It …

Early‐Life Adversity and Blunted Stress Reactivity as Predictors of Alcohol and Drug use in Persons With COMT (rs4680) Val158Met Genotypes

WR Lovallo, AJ Cohoon, KH Sorocco… - Alcoholism: Clinical …, 2019 - Wiley Online Library
Background Risk for alcoholism may be enhanced by exposure to early‐life adversity (ELA)
in persons with genetic vulnerabilities. We examined ELA in the presence of a common …

How to consistently link extraversion and intelligence to the catechol-O-methyltransferase (COMT) gene: on defining and measuring psychological phenotypes in …

J Wacker, EM Mueller, J Hennig… - Journal of Personality …, 2012 - psycnet.apa.org
The evidence for associations between genetic polymorphisms and complex behavioral/
psychological phenotypes (traits) has thus far been weak and inconsistent. Using the well …

Joint impact of early life adversity and COMT Val158Met (rs4680) genotypes on the adult cortisol response to psychological stress

WR Lovallo, MA Enoch, KH Sorocco… - Psychosomatic …, 2017 - journals.lww.com
Objective Exposure to stress during critical periods of development can diminish stress
reactivity by the hypothalamic-pituitary-adrenocortical axis. Genetic characteristics may …

Cognitive effects of nicotine: genetic moderators

AI Herman, M Sofuoglu - Addiction biology, 2010 - Wiley Online Library
Cigarette smoking is the main preventable cause of death in developed countries, and the
development of more effective treatments is necessary. Cumulating evidence suggests that …

COMT as a drug target for cognitive functions and dysfunctions

D Scheggia, S Sannino… - CNS & Neurological …, 2012 - ingentaconnect.com
Catechol-O-methyltransferase (COMT) is a promising target for modulation of cognitive
functions and dysfunctions. COMT dominates the regulation of dopamine metabolism in the …

[HTML][HTML] Genetic susceptibility to parenting style: DRD2 and COMT influence creativity

S Si, Y Su, S Zhang, J Zhang - NeuroImage, 2020 - Elsevier
The present study systematically investigated if genetic variations in the DRD2 and COMT
interacted with parenting style to predict individual differences in creativity. In a sample of …