Association between behavioural risks and Alzheimer's disease: Elucidated with an integrated analysis of gene expression patterns and molecular mechanisms

D Li, H Yang, M Lyu, L Zhou, Y Zhang, C Kang… - Neuroscience & …, 2023 - Elsevier
Alzheimer's disease (AD) remains a global health challenge. Previous studies have reported
linkages between AD and multiple behavioural risk exposures, however, the underlying …

Personalized management and treatment of Alzheimer's disease

R Cacabelos, V Naidoo, O Martínez-Iglesias, L Corzo… - Life, 2022 - mdpi.com
Alzheimer's disease (AD) is a priority health problem with a high cost to society and a large
consumption of medical and social resources. The management of AD patients is complex …

Cognitive Deficits and Alzheimer's Disease-Like Pathologies in the Aged Chinese Tree Shrew

H Li, BL Xiang, X Li, C Li, Y Li, Y Miao, GL Ma… - Molecular …, 2024 - Springer
Alzheimer's disease (AD) is the most common chronic progressive neurodegenerative
disease in the elderly. It has an increasing prevalence and a growing health burden. One of …

Amylin and Secretases in the Pathology and Treatment of Alzheimer's Disease

S Singh, F Yang, A Sivils, V Cegielski, XP Chu - Biomolecules, 2022 - mdpi.com
Alzheimer's disease remains a prevailing neurodegenerative condition which has an array
physical, emotional, and financial consequences to patients and society. In the past decade …

The protective effect of mangiferin on formaldehyde-induced HT22 cell damage and cognitive impairment

F Chen, N Wang, X Tian, J Su, Y Qin, R He, X He - Pharmaceutics, 2023 - mdpi.com
Formaldehyde (FA) has been found to induce major Alzheimer's disease (AD)-like features
including cognitive impairment, Aβ deposition, and Tau hyperphosphorylation, suggesting …

Therapy and diagnosis of Alzheimer's disease: from discrete metal complexes to metal–organic frameworks

A García-García, S Rojas… - Journal of Materials …, 2023 - pubs.rsc.org
Alzheimer's disease (AD) is a neurodegenerative disorder affecting 44 million people
worldwide. Although many issues (pathogenesis, genetics, clinical features, and …

Inhibition of Alzheimer's disease by 4-octyl itaconate revealed by RNA-seq transcriptome analysis

Y Liu, P Xia, S Zong, N Zheng, X Cui, C Wang… - European Journal of …, 2024 - Elsevier
Aims This study aimed to examine the therapeutic effects and response mechanisms of 4-OI
in Alzheimer's disease (AD). Methods In this study, network pharmacology was employed to …

Mitochondrial damage-induced abnormal glucose metabolism with ageing in the hippocampus of APP/PS1 mice

S Li, Y Wang, X Zhang, X Xiong, F Zhou, X Li, J Fan… - Metabolomics, 2023 - Springer
Introduction Accumulation of β-amyloid (Aβ) in neurons of patients with Alzheimer's disease
(AD) inhibits the activity of key enzymes in mitochondrial metabolic pathways, triggering …

The role of visual rating and automated brain volumetry in early detection and differential diagnosis of Alzheimer's disease

Y Mai, Z Cao, L Zhao, Q Yu, J Xu, W Liu… - CNS Neuroscience …, 2024 - Wiley Online Library
Background Medial temporal lobe atrophy (MTA) is a diagnostic marker for mild cognitive
impairment (MCI) and Alzheimer's disease (AD), but the accuracy of quantitative MTA …

β-Amyloid peptide modulates peripheral immune responses and neuroinflammation in rats

K Adhikary, S Mohanty, B Bandyopadhyay… - Biomolecular …, 2024 - degruyter.com
Alzheimer's disease (AD) is characterized by immune system dysregulation, impacting both
central and peripheral immune responses. The study aimed to investigate the mechanism …