Besides the physiological regulation of water, sodium, and potassium homeostasis,
aldosterone modulates several physiological and pathological processes in the …

Primary aldosteronism is a common cause of hypertension and is a risk factor for
cardiovascular and renal morbidity and mortality, via mechanisms mediated by both …

Background: Primary aldosteronism is a nonsuppressible renin-independent aldosterone
production that causes hypertension and cardiovascular disease. Objective: To characterize …

Autonomous aldosterone overproduction represents the underlying condition of 5–10% of
patients with arterial hypertension and carries a significant burden of mortality and morbidity …

We are witnessing a revolution in our understanding of primary aldosteronism (PA). In the
past 2 decades, we have learned that PA is a highly prevalent syndrome that is largely …

Early diagnosis and appropriate treatment of primary aldosteronism, the most frequent
cause of secondary hypertension, are crucial to prevent deleterious cardiovascular …

Context New approaches are needed to address the evolution of the primary aldosteronism
syndrome and to increase its recognition. Herein, we review evidence indicating that primary …

Primary aldosteronism is a frequent cause of secondary hypertension requiring a specific
pharmacological treatment with mineralocorticoid receptor antagonist or with unilateral …

Aims Randomized controlled trials have demonstrated the efficacy of mineralocorticoid
receptor (MR) antagonism in delaying chronic kidney disease (CKD) progression in …

Resistant hypertension is associated with higher rates of cardiovascular disease, kidney
disease, and death than primary hypertension. Although clinical practice guidelines …