Primary aldosteronism (PA), once considered a rare disease, is being increasingly
recognized as an important cause of hypertension. It is associated with higher rates of …

Background The prevalence of primary aldosteronism (PA) varies from 5% to 20% in
patients with hypertension but is largely underdiagnosed. Expanding screening for PA to all …

Background: Ion channel mutations in calcium regulating genes strongly associate with
AngII (angiotensin II)-independent aldosterone production. Here, we used an established …

Background Renin-independent aldosteronism (RIA) describes the spectrum of autonomous
aldosterone secretion from mild to overt. We aimed to explore whether RIA is causally …

Context Confirmatory tests represent a fundamental step in primary aldosteronism (PA)
diagnosis, but they are laborious and often require a hospital environment due to the risks …

Background Adrenal venous sampling (AVS) is recommended before adrenalectomy for
patients with primary aldosteronism (PA) over 35 years old. The literature examining …

Background Optimal management of primary aldosteronism (PA) is crucial due to the
increased risk of cardiovascular and cerebrovascular diseases. Adrenal venous sampling …

Context Adrenocorticotropic hormone (ACTH) can contribute to aldosterone excess in
primary aldosteronism (PA) via increased melanocortin type 2 receptor expression. Dynamic …

Context Complex relationships between aldosterone and calcium homeostasis have been
proposed. Objective To disentangle the influence of aldosterone and intravascular volume …

In the present study, we developed a new chemiluminescent enzyme immunoassay (CLEIA)
using a two-step sandwich method to measure aldosterone concentrations. We investigated …