Abstract Histone deacetylase 6 (HDAC6) is a critical target for drug design because of its
role in oncogenic transformation and cancer metastasis, and is unique among all histone …

SUMOylation is a reversible post-translational modification which has emerged as a crucial
molecular regulatory mechanism, involved in the regulation of DNA damage repair, immune …

The ever-increasing prevalence of noncommunicable diseases (NCDs) represents a major
public health burden worldwide. The most common form of NCD is metabolic diseases …

The physiological identity of every cell is maintained by highly specific transcriptional
networks that establish a coherent molecular program that is in tune with nutritional …

The process of aging and circadian rhythms are intimately intertwined, but how peripheral
clocks involved in metabolic homeostasis contribute to aging remains unknown. Importantly …

Background The diminished glucose lowering effect of insulin in obesity, called “insulin
resistance,” is associated with glucose intolerance, type 2 diabetes, and other serious …

Gene regulation is a complex and tightly controlled process that defines cell identity, health
and disease, and response to pharmacologic and environmental signals. Recently …

Besides the conventional carbon sources, acetyl-CoA has recently been shown to be
generated from acetate in various types of cancers, where it promotes lipid synthesis and …

Post-translational modification of lysine residues via reversible acylation occurs on proteins
from diverse pathways, functions, and organisms. While nuclear protein acylation reflects the …

The presence of DNA in the cytoplasm is normally a sign of microbial infections and is
quickly detected by cyclic GMP-AMP synthase (cGAS) to elicit anti-infection immune …