Lysine acetylation (Kac) is well known to occur in histones for chromatin function and
epigenetic regulation. In addition to histones, Kac is also detected in a large number of …

Background: Worldwide, diabetes mellitus and heart failure represent frequent comorbidities
with high socioeconomic impact and steadily growing incidence, calling for a better …

Chemical modifications to nucleosomal DNA and histone tails greatly influence transcription
of adjacent and distant genes, a mode of gene regulation referred to as epigenetic control …

Although a conserved SAGA complex containing the histone acetyltransferase GCN5 is
known to mediate histone acetylation and transcriptional activation in eukaryotes, how to …

Over 50% of patients with heart failure have preserved ejection fraction (HFpEF), rather than
reduced ejection fraction (HFrEF). The prevalence of HFpEF continues to increase, while the …

Lysine acetylation, one of the major types of post-translational modifications, plays critical
roles in regulating gene expression and protein function. Histone deacetylases (HDACs) are …

Epigenetic regulation of gene expression is important for plant adaptation to environmental
changes. Previous results showed that Arabidopsis RPD3-like histone deacetylase HDA9 is …

Acetylation of histone H3K23 has emerged as an essential posttranslational modification
associated with cancer and learning and memory impairment, yet our understanding of this …

Various post-translational modifications can naturally occur on proteins, regulating the
activity, subcellular localization, interaction, or stability of the proteins. However, it can be …

Ketone bodies are crucial intermediate metabolites widely associated with treating
metabolic diseases. Accumulating evidence suggests that ketone bodies may act as …