Histone acetylation is a predominant active chromatin mark deposited by histone
acetyltransferases (HATs) that transfer the acetyl group from acetyl coenzyme A (acetyl-CoA) …

The retinoblastoma protein (pRb) functions as a cell cycle regulator controlling G1 to S
phase transition and plays critical roles in tumour suppression. It is frequently inactivated in …

Two-dimensional gel electrophoresis was instrumental in the birth of proteomics in the late
1980s. However, it is now often considered as an outdated technique for proteomics—a …

Ethylene plays pleiotropic roles in plant growth, plant development, and stress responses.
Although the effects of ethylene on plants are well documented, little is known about …

Chromatin-based DNA damage response (DDR) pathways are fundamental for preventing
genome and epigenome instability, which are prevalent in cancer. Histone …

Chemical modifications on histones constitute a key mechanism for gene regulation in
chromatin context. Recently, histone lysine β-hydroxybutyrylation (Kbhb) was identified as a …

Drought stress, a major environmental factor, significantly affects plant growth and
reproduction. Plants have evolved complex molecular mechanisms to tolerate drought …

Perturbation of metabolism elicits cellular stress which profoundly modulates the cellular
proteome and thus protein homeostasis (proteostasis). Consequently, changes in the …

ABSTRACT TFEB (transcription factor EB) is a master regulator of lysosomal biogenesis,
function and autophagy. The transcriptional activity of TFEB is mainly controlled by its …

The Soviet agronomist Trofim Lysenko became one of the most notorious figures in twentieth-
century science after his genetic theories were discredited decades ago. Yet some …