Increasing evidence suggests that mechanics play a critical role in regulating brain function
at different scales. Downstream integration of mechanical inputs into biochemical signals …

Cell motility is a crucial biological process that plays a critical role in the development of
multicellular organisms and is essential for tissue formation and regeneration. However …

Neuroblastoma (NB) is the most common extracranial tumor in children resulting in
substantial morbidity and mortality. A deeper understanding of the NB tumor …

With the biological relevance of the whole cells, low cost compared with animal experiments,
a wide variety of cell-based screening platforms (cell-based assay, cell-based microfluidics …

Over the past decade, immunotherapy has represented an enormous step forward in the
fight against cancer. Immunotherapeutic approaches have increasingly become a …

In vitro metastatic models are foreseen to introduce a breakthrough in the field of preclinical
screening of more functional small-molecule pharmaceuticals and biologics. To achieve this …

Neuroblastoma (NB) is a pediatric neuroendocrine neoplasm. It arises from the sympatho-
adrenal lineage of neural-crest-derived multipotent progenitor cells that fail to differentiate …

Simple Summary Neuroblastoma is a pediatric tumor originating from the precursors of
sympathetic nerves. The disease is known for its high heterogeneity. Hence, developing …

Simple Summary Drug development and therapeutic approaches for treating cancer have
shifted towards incorporating more multimodality approaches that harness the immune …

In the quest to advance neuroblastoma therapeutics, there is a need to have a deeper
understanding of the tumor microenvironment (TME). From extracellular matrix proteins to …