Brain development is an extraordinarily complex process achieved through the spatially and
temporally regulated release of key patterning factors. In vitro neurodevelopmental models …

Glia constitute roughly half of the cells of the central nervous system (CNS) but were long-
considered to be static bystanders to its formation and function. Here we provide an …

Neanderthal brains were similar in size to those of modern humans. We sought to
investigate potential differences in neurogenesis during neocortex development. Modern …

Although Huntington's disease is a late-manifesting neurodegenerative disorder, both
mouse studies and neuroimaging studies of presymptomatic mutation carriers suggest that …

Summary N 6-methyladenosine (m 6 A), installed by the Mettl3/Mettl14 methyltransferase
complex, is the most prevalent internal mRNA modification. Whether m 6 A regulates …

Astrocytes are a population of cells with distinctive morphological and functional
characteristics that differ within specific areas of the brain. Postnatally, astrocyte progenitors …

Understanding human embryonic ventral midbrain is of major interest for Parkinson's
disease. However, the cell types, their gene expression dynamics, and their relationship to …

Precise temporal control of gene expression in neuronal progenitors is necessary for correct
regulation of neurogenesis and cell fate specification. However, the cellular heterogeneity of …

The cerebral cortex underwent rapid expansion and increased complexity during recent
hominid evolution. Gene duplications constitute a major evolutionary force, but their impact …

Cerebral organoids—3D cultures of human cerebral tissue derived from pluripotent stem
cells—have emerged as models of human cortical development. However, the extent to …