The heterogeneity of Parkinson's disease

U Wüllner, P Borghammer, C Choe, I Csoti… - Journal of Neural …, 2023 - Springer
The heterogeneity of Parkinson's disease (PD), ie the various clinical phenotypes,
pathological findings, genetic predispositions and probably also the various implicated …

The interplay between gut microbiota and Parkinson's disease: Implications on diagnosis and treatment

A Varesi, LIM Campagnoli, F Fahmideh… - International journal of …, 2022 - mdpi.com
The bidirectional interaction between the gut microbiota (GM) and the Central Nervous
System, the so-called gut microbiota brain axis (GMBA), deeply affects brain function and …

Immunological shifts during early-stage Parkinson's disease identified with DNA methylation data on longitudinally collected blood samples

SC Pike, M Havrda, F Gilli, Z Zhang, LA Salas - npj Parkinson's Disease, 2024 - nature.com
Parkinson's disease (PD) is the second most common neurodegenerative disease in the
United States. Decades before motor symptoms manifest, non-motor symptoms such as …

The classical and non-classical axes of renin-angiotensin system in Parkinson disease: the bright and dark side of the moon

HM Al-Kuraishy, SM Al-Hamash, MS Jabir… - Ageing Research …, 2024 - Elsevier
Parkinson disease (PD) is a common brain neurodegenerative disease due to progressive
degeneration of the dopaminergic neurons in the substantia nigra pars compacta (SNpc). Of …

SARS-CoV-2 and Parkinson's Disease: A Review of Where We Are Now

I Boura, MA Qamar, F Daddoveri, V Leta… - Biomedicines, 2023 - mdpi.com
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which causes coronavirus
disease 2019 (COVID-19), has been discussed in the context of Parkinson's disease (PD) …

A Parkinson's Auxiliary Diagnosis Algorithm Based on a Hyperparameter Optimization Method of Deep Learning

X Wang, S Li, CM Pun, Y Guo, F Xu… - … /ACM Transactions on …, 2023 - ieeexplore.ieee.org
Parkinson's disease is a common mental disease in the world, especially in the middle-aged
and elderly groups. Today, clinical diagnosis is the main diagnostic method of Parkinson's …

Dopamine transmission imbalance in neuroinflammation: perspectives on long-term COVID-19

M Mancini, S Natoli, F Gardoni, M Di Luca… - International Journal of …, 2023 - mdpi.com
Dopamine (DA) is a key neurotransmitter in the basal ganglia, implicated in the control of
movement and motivation. Alteration of DA levels is central in Parkinson's disease (PD), a …

Experimental models to study immune dysfunction in the pathogenesis of Parkinson's disease

J Saponjic, R Mejías, N Nikolovski, M Dragic… - International journal of …, 2024 - mdpi.com
Parkinson's disease (PD) is a chronic, age-related, progressive multisystem disease
associated with neuroinflammation and immune dysfunction. This review discusses the …

Cytokine activity in Parkinson's disease

N Dzamko - Neuronal Signaling, 2023 - portlandpress.com
The contribution of the immune system to the pathophysiology of neurodegenerative
Parkinson's disease (PD) is increasingly being recognised, with alterations in the innate and …

Virus-induced brain pathology and the neuroinflammation-inflammation continuum: the neurochemists view

J Sian-Hulsmann, P Riederer - Journal of Neural Transmission, 2024 - Springer
Fascinatingly, an abundance of recent studies has subscribed to the importance of cytotoxic
immune mechanisms that appear to increase the risk/trigger for many progressive …