COVID-19 therapeutics: Challenges and directions for the future
PC Robinson, DFL Liew, HL Tanner… - Proceedings of the …, 2022 - National Acad Sciences
The emergence of SARS-CoV-2 triggering the COVID-19 pandemic ranks as arguably the
greatest medical emergency of the last century. COVID-19 has highlighted health disparities …
greatest medical emergency of the last century. COVID-19 has highlighted health disparities …
Neutrophil activation and neutrophil extracellular traps (NETs) in COVID‐19 ARDS and immunothrombosis
MC Cesta, M Zippoli, C Marsiglia… - European Journal of …, 2023 - Wiley Online Library
Acute respiratory distress syndrome (ARDS) is an acute inflammatory condition with a
dramatic increase in incidence since the beginning of the coronavirus disease 19 (COVID …
dramatic increase in incidence since the beginning of the coronavirus disease 19 (COVID …
[HTML][HTML] The spatial landscape of lung pathology during COVID-19 progression
Recent studies have provided insights into the pathology of and immune response to COVID-
19,,,,,,–. However, a thorough investigation of the interplay between infected cells and the …
19,,,,,,–. However, a thorough investigation of the interplay between infected cells and the …
[HTML][HTML] Whole-genome sequencing reveals host factors underlying critical COVID-19
A Kousathanas, E Pairo-Castineira, K Rawlik… - Nature, 2022 - nature.com
Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic
variation influences the development of illness requiring critical care or hospitalization,–after …
variation influences the development of illness requiring critical care or hospitalization,–after …
A persistent neutrophil-associated immune signature characterizes post–COVID-19 pulmonary sequelae
Interstitial lung disease and associated fibrosis occur in a proportion of individuals who have
recovered from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection …
recovered from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection …
Mitochondrial translation is required for sustained killing by cytotoxic T cells
M Lisci, PR Barton, LO Randzavola, CY Ma… - Science, 2021 - science.org
INTRODUCTION Cytotoxic T lymphocytes (CTLs) are important cells within the immune
system that are able to recognize and destroy cancer and virally infected cells. Killing is …
system that are able to recognize and destroy cancer and virally infected cells. Killing is …
Blood-brain crosstalk: the roles of neutrophils, platelets, and neutrophil extracellular traps in neuropathologies
Systemic inflammation, neurovascular dysfunction, and coagulopathy often occur
concurrently in neuropathologies. Neutrophils and platelets have crucial synergistic roles in …
concurrently in neuropathologies. Neutrophils and platelets have crucial synergistic roles in …
[HTML][HTML] Neutrophil metabolomics in severe COVID-19 reveal GAPDH as a suppressor of neutrophil extracellular trap formation
Severe COVID-19 is characterized by an increase in the number and changes in the
function of innate immune cells including neutrophils. However, it is not known how the …
function of innate immune cells including neutrophils. However, it is not known how the …
[HTML][HTML] Oncogenic signals prime cancer cells for toxic cell overgrowth during a G1 cell cycle arrest
CDK4/6 inhibitors are remarkable anti-cancer drugs that can arrest tumor cells in G1 and
induce their senescence while causing only relatively mild toxicities in healthy tissues. How …
induce their senescence while causing only relatively mild toxicities in healthy tissues. How …
[HTML][HTML] Circulating type I interferon levels and COVID-19 severity: a systematic review and meta-analysis
RP Da Silva, JIB Gonçalves, RF Zanin… - Frontiers in …, 2021 - frontiersin.org
Introduction Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) infections, resulting in a range of clinical …
syndrome coronavirus 2 (SARS-CoV-2) infections, resulting in a range of clinical …