Bench-to-bedside: Innovation of small molecule anti-SARS-CoV-2 drugs in China

L Yang, Z Wang - European Journal of Medicinal Chemistry, 2023 - Elsevier
The ongoing COVID-19 pandemic has resulted in millions of deaths globally, highlighting
the need to develop potent prophylactic and therapeutic strategies against SARS-CoV-2 …

[HTML][HTML] Oral GS-441524 derivatives: Next-generation inhibitors of SARS‐CoV‐2 RNA‐dependent RNA polymerase

Z Wang, L Yang, X Song - Frontiers in Immunology, 2022 - frontiersin.org
GS-441524, an RNA‐dependent RNA polymerase (RdRp) inhibitor, is a 1′-CN-substituted
adenine C-nucleoside analog with broad-spectrum antiviral activity. However, the low oral …

[HTML][HTML] The therapeutic potential of natural dietary flavonoids against SARS-CoV-2 infection

Z Wang, L Yang - Nutrients, 2023 - mdpi.com
The exploration of non-toxic and cost-effective dietary components, such as epigallocatechin
3-gallate and myricetin, for health improvement and disease treatment has recently attracted …

[HTML][HTML] An overview of potential natural photosensitizers in cancer photodynamic therapy

B Aziz, I Aziz, A Khurshid, E Raoufi, FN Esfahani… - Biomedicines, 2023 - mdpi.com
Cancer is one of the main causes of death worldwide. There are several different types of
cancer recognized thus far, which can be treated by different approaches including surgery …

[HTML][HTML] Serial viral load analysis by DDPCR to evaluate FNC efficacy and safety in the treatment of mild cases of COVID-19

RM da Silva, P Gebe Abreu Cabral… - Frontiers in …, 2023 - frontiersin.org
Introduction: The SARS-CoV-2 outbreak has threatened the human population globally as
the numbers of reinfection cases even after large-scale vaccination. Trials have been carried …

[HTML][HTML] The envelope (E) protein of SARS-coV-2 as a pharmacological target

T Santos-Mendoza - Viruses, 2023 - mdpi.com
The COVID-19 pandemic caused by the SARS-CoV-2 virus is still a global health concern.
Several spike (S) protein-based vaccines have been developed that efficiently protect the …

[HTML][HTML] Effectiveness, tolerability and prescribing choice of antiviral molecules molnupiravir, remdesivir and nirmatrelvir/r: a real-world comparison in the first ten …

C Del Borgo, S Garattini, C Bortignon, A Carraro… - Viruses, 2023 - mdpi.com
In 2022, three antiviral drugs—molnupiravir, remdesivir and nirmatrelvir/ritonavir—were
introduced for treatment of mild-to-moderate COVID-19 in high-risk patients. The aim of this …

[HTML][HTML] Natural-product-based, carrier-free, noncovalent nanoparticles for tumor chemo-photodynamic combination therapy

Z Wang, L Yang - Pharmacological Research, 2024 - Elsevier
Cancer, with its diversity, heterogeneity, and complexity, is a significant contributor to global
morbidity, disability, and mortality, highlighting the necessity for transformative treatment …

[HTML][HTML] Effectiveness of oral nirmatrelvir/ritonavir vs. intravenous three-day remdesivir in preventing progression to severe COVID-19: a single-center, prospective …

D Basoulis, A Tsakanikas, A Gkoufa, A Bitsani… - Viruses, 2023 - mdpi.com
Background: Nirmatrelvir/ritonavir (NMV/r) and three-day course remdesivir (3RDV) have
been approved as early treatments for COVID-19 outpatients not requiring supplemental …

[HTML][HTML] Microalgal carotenoids: therapeutic application and latest approaches to enhance the production

P Sirohi, H Verma, SK Singh, VK Singh… - Current Issues in …, 2022 - mdpi.com
Microalgae are microscopic photosynthetic organisms frequently found in fresh and marine
water ecosystems. Various microalgal species have been considered a reservoir of diverse …