[HTML][HTML] In vitro and in vivo pharmacodynamic activity of the new compound XC221GI in models of the viral inflammation of the respiratory tract

МА Stukova, AV Rydlovskaya… - Microbiology …, 2022 - cyberleninka.ru
The viruses that most commonly affect human respiratory tract include rhinoviruses,
respiratory syncytial viruses (RSVs), influenza, and coronaviruses (CoVs). The virus …

Exome-wide association study reveals host genetic variants likely associated with the severity of COVID-19 in patients of European ancestry

P Upadhyai, PU Shenoy, B Banjan, MF Albeshr… - Life, 2022 - mdpi.com
Host genetic variability plays a pivotal role in modulating COVID-19 clinical outcomes.
Despite the functional relevance of protein-coding regions, rare variants located here are …

[HTML][HTML] Фармакодинамическая активность нового соединения XC221GI в in vitro и in vivo моделях вирусного воспаления респираторного тракта

МА Стукова, АВ Рыдловская… - Microbiology …, 2022 - cyberleninka.ru
Вирусы, наиболее часто поражающие респираторный тракт человека, включают
риновирусы, респираторно-синцитиальный вирус (РСВ), вирусы гриппа и …

[HTML][HTML] Co-infecting pathogens can contribute to inflammatory responses and severe symptoms in COVID-19

L Chen, L Shen, W Wu, W Guan, J Zhou… - Journal of Thoracic …, 2022 - ncbi.nlm.nih.gov
Background The current COVID-19 pandemic is posing a major challenge to public health
on a global scale. While it is generally believed that severe COVID-19 results from over …

Absence of “Cytokine Storm” in hospitalized COVID-19 patients: A retrospective cohort study

ML Ciampa, TA O'Hara, CL Joel, MM Gleaton… - Infectious Disease …, 2021 - mdpi.com
Background: A rapidly growing number of publications cite “cytokine storm” as a contributing
factor in coronavirus disease 2019 (COVID-19) pathology. However, a few recent reports led …

[HTML][HTML] Severe COVID-19 pneumonia is associated with increased plasma immunoglobulin G agonist autoantibodies targeting the 5-hydroxytryptamine 2a receptor

MB Zimering - Endocrinology, diabetes and metabolism journal, 2021 - ncbi.nlm.nih.gov
Aims: To test whether plasma autoantibodies targeting the 5-hydroxytryptamine 2A receptor
increase in COVID-19 infection; and to characterize the pharmacologic specificity, and …

[PDF][PDF] Markers of inflammasome activation in Coronavirus disease 2019 (COVID-19) Egyptian patients: Impact on disease severity

SK Abd El-Aty, SH Ahmed, RF Abd El-Hamid… - Egypt J …, 2023 - ejimmunology.org
There are conflicting data regarding the relationship between coronavirus disease 2019
(COVID-19) severity and Caspase-1 (Casp-1), interleukin-1ß (IL-1β), and IL-18. Our study …

Pharmacologic Therapeutics for COVID‐19

AM Burkhardt, A Lu, I Asante… - … Disease 2019 (COVID‐19 …, 2023 - Wiley Online Library
Due to its highly transmissive nature, the COVID‐19 pandemic caused by the severe acute
respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has created a significant burden on …

A replicon RNA vaccine induces durable protective immunity from SARS-CoV-2 in nonhuman primates after neutralizing antibodies have waned

MA O'Connor, DW Hawman, K Meade-White… - bioRxiv, 2022 - biorxiv.org
The global SARS-CoV-2 pandemic prompted rapid development of COVID-19 vaccines.
Although several vaccines have received emergency approval through various public health …

Caspases in COVID-19 disease and sequela and the therapeutic potential of caspase inhibitors

M Plassmeyer, O Alpan, MJ Corley, K Lillard… - medRxiv, 2020 - medrxiv.org
Currently, there is no effective vaccine and only one FDA approved early-stage therapy
against SARS-CoV-2 infection as an indication to prevent disease progression. Cellular …