To commemorate the auspicious occasion of the 30th anniversary of IPC, leading pioneers
in the field of cardioprotection gathered in Barcelona in May 2016 to review and discuss the …

Reperfusion of the heart after a period of ischaemia leads to the opening of a nonspecific
pore in the inner mitochondrial membrane, known as the mitochondrial permeability …

Mitochondria play a key role in determining cell fate during exposure to stress. Their role
during ischemia/reperfusion is particularly critical because of the conditions that promote …

Objective: We propose that ischemic preconditioning (IPC) and mitochondrial KATP channel
activation protect the myocardium by inhibiting mitochondrial permeability transition pore …

Mitochondria are important generators of energy, providing ATP through oxidative
phosphorylation. However, mitochondria also monitor complex information from the …

Although functional coupling between protein kinase Cε (PKCε) and mitochondria has been
implicated in the genesis of cardioprotection, the signal transduction mechanisms that …

Ischemia and post-ischemic reperfusion cause a wide array of functional and structural
alterations of mitochondria. Although mitochondrial impairment is recognized as pivotal in …

Although activation of protein kinase C (PKC) ε and mitogen-activated protein kinases
(MAPKs) are known to play crucial roles in the manifestation of cardioprotection, the spatial …

Despite current optimal treatment, the morbidity and mortality of coronary heart disease
(CHD), the leading cause of death worldwide, remains significant, paving the way for the …

In addition to their central role in ATP synthesis, mitochondria play a critical role in cell
death. Oxidative stress accompanied by calcium overload, ATP depletion, and elevated …