Natural killer (NK) cells, which are innate lymphocytes endowed with potent cytotoxic
activity, have recently attracted attention as potential anticancer therapeutics. While NK cells …

The progression of cancer involves a critical step in which malignant cells escape from
control by the immune system. Antineoplastic agents are particularly efficient when they …

Immunotherapies have revolutionized the treatment paradigms of various types of cancers.
However, most of these immunomodulatory strategies focus on harnessing adaptive …

Spheroids and organoids are important novel players in medical and life science research.
They are gradually replacing two-dimensional (2D) cell cultures. Indeed, three-dimensional …

Objective The role of N6-methyladenosine (m6A) in tumour immune microenvironment
(TIME) remains understudied. Here, we elucidate function and mechanism of YTH N6 …

Ethnopharmacological relevance Smilax china L., an extensively used traditional Chinese
medicine, is known as Baqia in China. It has been used to treat various inflammatory …

Depletion of CD8+ T cells is a major obstacle in immunotherapy; however, the relevant
mechanisms remain largely unknown. Here, we showed that prostate cancer (PCa) cell …

The immune landscape of bladder cancer progression is not fully understood, and effective
therapies are lacking in advanced bladder cancer. Here, we visualized that bladder cancer …

Radiation is a curative treatment for localized prostate cancer (PCa). Unfortunately,
radiotherapeutic efficacy is often diminished when patients develop more aggressive or …

The incidence and mortality of lung cancer are on the rise worldwide. However, the benefit
of clinical treatment in lung cancer is limited. Owning to important sources of drug …