The tight association of the human body with trillions of colonizing microbes that we observe
today is the result of a long evolutionary history. Only very recently have we started to …

Osteosarcoma is the most common primary bone malignancy in children and adolescents.
Although improvements in therapeutic strategies were achieved, the outcome remains poor …

The current research was aimed at probing into the role of long noncoding RNA (lncRNA)
PVT1 in the pathogenesis of glioma and the regulatory mechanism of PVT1/miR-128 …

Noncoding RNAs (ncRNAs) play crucial roles in many biological processes. Experimental
methods for identifying ncRNA–protein interactions (NPIs) are always costly and time …

Although often located at a distance from their target gene promoters, enhancers are the
primary genomic determinants of temporal and spatial transcriptional specificity in …

Background There is increasing evidence in support of the role of lncRNAs in tumor cell
proliferation, differentiation and apoptosis. Methods We examined the expression of the …

Epigenetic processes in the brain involve the transfer of information arising from short-lived
cellular signals and changes in neuronal activity into lasting effects on gene expression. Key …

DNA methylation of cytosine residues is a stable epigenetic alteration, beginning as early as
foetal development in the uterus and continuously evolving throughout life. DNA methylation …

Long noncoding RNAs (lncRNAs) are rapidly emerging as important regulators of gene
expression in a wide variety of physiological and pathological cellular processes. In …

Bladder cancer (BCa) belongs to a popular urological malignancy and leads to large
numbers of deaths worldwide. Recently, emerging evidences indicate that long noncoding …