Last year saw a breakthrough in protein structure prediction, where the AlphaFold2 method
showed a substantial improvement in the modeling accuracy. Following the software release …

Abstract The Database of Intrinsically Disordered Proteins (DisProt, URL: https://disprot. org)
is the major repository of manually curated annotations of intrinsically disordered proteins …

Intrinsically disordered proteins (IDPs) constitute a broad set of proteins with few uniting and
many diverging properties. IDPs—and intrinsically disordered regions (IDRs) interspersed …

For proteins, the sequence→ structure→ function paradigm applies primarily to enzymes,
transmembrane proteins, and signaling domains. This paradigm is not universal, but rather …

Intrinsic disorder is instrumental for a wide range of protein functions, and its analysis, using
computational predictions from primary structures, complements secondary and tertiary …

Effectors play a central role in determining the outcome of plant− pathogen interactions. As
key virulence proteins, effectors are collectively indispensable for disease development. By …

Motivation Intrinsically disordered protein regions interact with proteins, nucleic acids and
lipids. Regions that bind lipids are implicated in a wide spectrum of cellular functions and …

Abstract DisProt (URL: https://disprot. org) is the gold standard database for intrinsically
disordered proteins and regions, providing valuable information about their functions. The …

Intrinsic disorder in proteins is relatively abundant in nature and essential for a broad
spectrum of cellular functions. While disorder can be accurately predicted from protein …

Proteins may vary from being rigid to having flexible regions to being completely disordered,
either as an intrinsically disordered protein (IDP) or having specific intrinsically disordered …