Determining intrinsically disordered regions of proteins is essential for elucidating protein
biological functions and the mechanisms of their associated diseases. As the gap between …

Recent studies reveal that de novo gene origination from previously non-genic sequences is
a common mechanism for gene innovation. These young genes provide an opportunity to …

Protein intrinsic disorder (ID) is a complex and context‐dependent phenomenon that covers
a continuum between fully disordered states and folded states with long dynamic regions …

Predictions for millions of protein three-dimensional structures are only a few clicks away
since the release of AlphaFold2 results for UniProt. However, many proteins have so-called …

AlphaFold2 (AF2) has created a breakthrough in biology by providing three-dimensional
structure models for whole-proteome sequences, with unprecedented levels of accuracy. In …

The key proteins involved in transcriptional regulation play convergent roles in cellular
homeostasis, and their dysfunction mediates aberrant gene expressions that underline the …

Ferritin is a vital protein complex responsible for storing iron in almost all living organisms. It
plays a crucial role in various metabolic pathways, inflammation processes, stress response …

Intrinsic disorder prediction is an active area that has developed over 100 predictors. We
identify and investigate a recent trend towards the development of deep neural network …

Identifying pathogenic missense variants in hereditary cancer is critical to the efforts of
patient surveillance and risk-reduction strategies. For this purpose, many different gene …

Lytic polysaccharide monooxygenases (LPMOs) are monocopper enzymes secreted by
many organisms and viruses. LPMOs catalyze the oxidative cleavage of different types of …