[HTML][HTML] Towards sequence-based principles for protein phase separation predictions
M Vendruscolo, M Fuxreiter - Current Opinion in Chemical Biology, 2023 - Elsevier
The phenomenon of protein phase separation, which underlies the formation of
biomolecular condensates, has been associated with numerous cellular functions. Recent …
biomolecular condensates, has been associated with numerous cellular functions. Recent …
Fast and accurate protein intrinsic disorder prediction by using a pretrained language model
Determining intrinsically disordered regions of proteins is essential for elucidating protein
biological functions and the mechanisms of their associated diseases. As the gap between …
biological functions and the mechanisms of their associated diseases. As the gap between …
Resources for computational prediction of intrinsic disorder in proteins
L Kurgan - Methods, 2022 - Elsevier
With over 40 years of research, researchers in the intrinsic disorder prediction field
developed over 100 computational predictors. This review offers a holistic perspective of this …
developed over 100 computational predictors. This review offers a holistic perspective of this …
DisP-seq reveals the genome-wide functional organization of DNA-associated disordered proteins
Intrinsically disordered regions (IDRs) in DNA-associated proteins are known to influence
gene regulation, but their distribution and cooperative functions in genome-wide regulatory …
gene regulation, but their distribution and cooperative functions in genome-wide regulatory …
Compositional bias of intrinsically disordered proteins and regions and their predictions
Intrinsically disordered regions (IDRs) carry out many cellular functions and vary in length
and placement in protein sequences. This diversity leads to variations in the underlying …
and placement in protein sequences. This diversity leads to variations in the underlying …
Oncogenic fusion proteins and their role in three-dimensional chromatin structure, phase separation, and cancer
Three-dimensional (3D) chromatin structure plays a critical role in development, gene
regulation, and cellular identity. Alterations to this structure can have profound effects on …
regulation, and cellular identity. Alterations to this structure can have profound effects on …
Characterization of intrinsically disordered regions in proteins informed by human genetic diversity
All proteomes contain both proteins and polypeptide segments that don't form a defined
three-dimensional structure yet are biologically active—called intrinsically disordered …
three-dimensional structure yet are biologically active—called intrinsically disordered …
Intrinsically disordered proteins: Perspective on COVID-19 infection and drug discovery
R Tenchov, QA Zhou - ACS Infectious Diseases, 2022 - ACS Publications
Since the beginning of the COVID-19 pandemic caused by SARS-CoV-2, millions of patients
have been diagnosed and many of them have died from the disease worldwide. The …
have been diagnosed and many of them have died from the disease worldwide. The …
Computational prediction of disordered binding regions
One of the key features of intrinsically disordered regions (IDRs) is their ability to interact
with a broad range of partner molecules. Multiple types of interacting IDRs were identified …
with a broad range of partner molecules. Multiple types of interacting IDRs were identified …
The protein interactome of the citrus Huanglongbing pathogen Candidatus Liberibacter asiaticus
Abstract The bacterium Candidatus Liberibacter asiaticus (CLas) causes citrus
Huanglongbing disease. Our understanding of the pathogenicity and biology of this …
Huanglongbing disease. Our understanding of the pathogenicity and biology of this …