Machine learning for intrinsic disorder prediction
Intrinsic disorder in proteins is manifested by regions that lack stable structure under
physiological conditions. Proteins with disordered regions are common across all kingdoms …
physiological conditions. Proteins with disordered regions are common across all kingdoms …
One step closer to the understanding of the relationship IDR-LCR-structure
Intrinsically disordered regions (IDRs) in protein sequences are emerging as functionally
important elements for interaction and regulation. While being generally flexible, we …
important elements for interaction and regulation. While being generally flexible, we …
DescribePROT in 2023: more, higher-quality and experimental annotations and improved data download options
The DescribePROT database of amino acid-level descriptors of protein structures and
functions was substantially expanded since its release in 2020. This expansion includes …
functions was substantially expanded since its release in 2020. This expansion includes …
Biophysical and Integrative Characterization of Protein Intrinsic Disorder as a Prime Target for Drug Discovery
Protein intrinsic disorder is increasingly recognized for its biological and disease-driven
functions. However, it represents significant challenges for biophysical studies due to its …
functions. However, it represents significant challenges for biophysical studies due to its …
HybridDBRpred: improved sequence-based prediction of DNA-binding amino acids using annotations from structured complexes and disordered proteins
Current predictors of DNA-binding residues (DBRs) from protein sequences belong to two
distinct groups, those trained on binding annotations extracted from structured protein-DNA …
distinct groups, those trained on binding annotations extracted from structured protein-DNA …
[HTML][HTML] An issue of concern: unique truncated ORF8 protein variants of SARS-CoV-2
An issue of concern: unique truncated ORF8 protein variants of SARS-CoV-2 [PeerJ] Related
research Download Share Twitter Facebook Email PEER-REVIEWED An issue of concern …
research Download Share Twitter Facebook Email PEER-REVIEWED An issue of concern …
Overview update: computational prediction of intrinsic disorder in proteins
VN Uversky, L Kurgan - Current Protocols, 2023 - Wiley Online Library
There are over 100 computational predictors of intrinsic disorder. These methods predict
amino acid‐level propensities for disorder directly from protein sequences. The propensities …
amino acid‐level propensities for disorder directly from protein sequences. The propensities …
Predicting protein conformational disorder and disordered binding sites
KC Tamburrini, G Pesce, J Nilsson… - Data Mining Techniques …, 2022 - Springer
In the last two decades it has become increasingly evident that a large number of proteins
adopt either a fully or a partially disordered conformation. Intrinsically disordered proteins …
adopt either a fully or a partially disordered conformation. Intrinsically disordered proteins …
Intrinsically disordered BMP4 morphogen and the beak of the finch: Co-option of an ancient axial patterning system
Darwin's finches, with the primary diversity in the shape and size of their beaks, represent an
excellent model system to study speciation and adaptive evolution. It is generally held that …
excellent model system to study speciation and adaptive evolution. It is generally held that …
Identification of Intrinsically Disordered Proteins and Regions in a Non-Model Insect Species Ostrinia nubilalis (Hbn.)
Research in previous decades has shown that intrinsically disordered proteins (IDPs) and
regions in proteins (IDRs) are as ubiquitous as highly ordered proteins. Despite this …
regions in proteins (IDRs) are as ubiquitous as highly ordered proteins. Despite this …