Aberrant patterns of brain functional connectivity in the default mode network (DMN) have
been observed across different classes of substance use disorder (SUD) and are associated …

Obsessive–compulsive disorder (OCD) is characterized by repetitive thoughts and
behaviours that are experienced as unwanted. Family and twin studies have demonstrated …

Dopamine is involved in drug reinforcement but its role in addiction is less clear. Here we
describe PET imaging studies that investigate dopamine's involvement in drug abuse in the …

Depression is one of the most prevalent and debilitating of the psychiatric disorders. Studies
have shown that cognitive therapy is as efficacious as antidepressant medication at treating …

Converging lines of research suggest that the hippocampal complex (HC) may have a role
in the pathophysiology of major depressive disorder (MDD). Although postmortem studies …

Context Obsessive-compulsive disorder (OCD) is clinically heterogeneous, yet most
previous functional neuroimaging studies grouped together patients with mixed symptoms …

Background Measurement of cortical γ-aminobutyric acid (GABA) and glutamate
concentrations is possible using proton magnetic resonance spectroscopy. An initial report …

Deep brain stimulation is a promising therapeutic approach for patients with treatment-
resistant obsessive-compulsive disorder, a condition linked to abnormalities in corticobasal …

Neurophysiological studies of major depression performed using PET imaging have shown
abnormalities of regional cerebral blood flow (CBF) and glucose metabolism in multiple …

Background Obsessive-compulsive disorder (OCD) is associated with regional hyperactivity
in cortico-striatal circuits. However, the large-scale patterns of abnormal neural connectivity …