Myocardial ischemia is a disease with high morbidity and mortality, for which reperfusion is
currently the standard intervention. However, the reperfusion may lead to further myocardial …

KATP channels are integral to the functions of many cells and tissues. The use of
electrophysiological methods has allowed for a detailed characterization of KATP channels …

Mitochondria play a central role in energy metabolism within the cell. Mitochondrial
dysfunctions lead to various neurodegenerative disorders and to the so-called …

The critical time for opening mitochondrial (mito) KATP channels, putative end effectors of
ischemic preconditioning (PC), was examined. In isolated rabbit hearts 29±3% of risk zone …

Events during ischemia/reperfusion (I/R) injury include: neutrophil‐mediated endothelial
cytotoxicity and activation, generation of free radicals, triggering of cytokines and …

Despite nearly twenty years of research into the field of ischemic preconditioning, the actual
mechanism of protection remains unclear. However, much progress has been made in …

Background Preconditioning by volatile anesthetics is a promising therapeutic strategy to
render myocardial tissue resistant to perioperative ischemia. It was hypothesized that …

Although activation of protein kinase C (PKC) ε and mitogen-activated protein kinases
(MAPKs) are known to play crucial roles in the manifestation of cardioprotection, the spatial …

Ischemic or myocardial preconditioning (IPC) is a phenomenon whereby brief periods of
ischemia have been shown to protect the myocardium against a more sustained ischemic …

Ischemic and pharmacological preconditioning can be triggered by an intracellular signaling
pathway in which Gi-coupled surface receptors activate a cascade including …