Removal of introns from messenger RNA precursors (pre-mRNA splicing) is an essential
step for the expression of most eukaryotic genes. Alternative splicing enables the regulated …

Single-cell RNA sequencing (scRNA-seq) technologies allow the dissection of gene
expression at single-cell resolution, which greatly revolutionizes transcriptomic studies. A …

Large panels of comprehensively characterized human cancer models, including the
Cancer Cell Line Encyclopedia (CCLE), have provided a rigorous framework with which to …

It is unclear how disease mutations impact intrinsically disordered protein regions (IDRs),
which lack a stable folded structure. These mutations, while prevalent in disease, are …

Alternative splicing is a tightly regulated process whereby non-coding sequences of pre-
mRNA are removed and protein-coding segments are assembled in diverse combinations …

Cancer is one of the most widespread challenges and important diseases, which has the
highest mortality rate. Lung cancer is the most common type of cancer, so that about 25% of …

Metal exposure is pervasive and not limited to sporadic poisoning events or toxic waste
sites. Hundreds of millions of people around the globe are affected by chronic metal …

Immunotherapies are yielding effective treatments for several previously untreatable
cancers. Still, the identification of suitable antigens specific to the tumour that can be targets …

Target-protein degradation is an emerging field in drug discovery and development. In
particular, the substrate-receptor proteins of the cullin–ubiquitin ligase system play a key …

Alternative splicing allows for the expression of multiple RNA and protein isoforms from one
gene, making it a major contributor to transcriptome and proteome diversification in …