Evidence has revealed that transcription factors play essential roles in regulation of multiple
cellular processes, including cell proliferation, metastasis, EMT, cancer stem cells and …

O-linked β-DN-acetylglucosamine (O-GlcNAc), as a posttranslational modification (PTM), is
a reversible reaction that attaches β-N-GlcNAc to Ser/Thr residues on specific proteins by O …

Histone methylation plays a key function in modulating gene expression, and preserving
genome integrity and epigenetic inheritance. However, aberrations of histone methylation …

Ethnopharmacological relevance Antrodia salmonea (AS), linked to the genus
Taiwanofungus, is a medicinal fungus, and exhibits anti-inflammatory, anti-oxidant, and …

The receptor tyrosine kinase orphan receptor 1 (ROR1) is a receptor for WNT5A and related
Wnt proteins, that play an important role during embryonic development by regulating cell …

Deubiquitination, a post-translational modification regulated by deubiquitinases, is essential
for cancer initiation and progression. Ubiquitin-specific proteases (USPs) are essential …

Cancer stem cells (CSCs) are a small subpopulation of cancer cells with capabilities of self-
renewal, differentiation, and tumorigenicity, and play a critical role in driving tumor …

Endometrial cancer (EC) is the third leading gynecological malignancy, and its treatment
remains challenging. B cell-specific Moloney murine leukemia virus integration site-1 (BMI1) …

Cancer stem cells (CSCs), a small subset of cells in tumors that are characterized by self-
renewal and continuous proliferation, lead to tumorigenesis, metastasis, and maintain tumor …

Epithelial–mesenchymal transition (EMT) is a metabolic process that confers phenotypic
flexibility to cells and the ability to adapt to new functions. This transition is critical during …