Biomedical research is undergoing a paradigm shift towards approaches centred on human
disease models owing to the notoriously high failure rates of the current drug development …

Organ-on-A-chip (OoAC) devices are miniaturized, functional, in vitro constructs that aim to
recapitulate the in vivo physiology of an organ using different cell types and extracellular …

We review the emergence of the new field of organ-on-a-chip (OOAC) engineering, from the
parent fields of tissue engineering and microfluidics. We place into perspective the tools and …

Drug evaluation has always been an important area of research in the pharmaceutical
industry. However, animal welfare protection and other shortcomings of traditional drug …

Despite tremendous progress in the development of mature heart-on-a-chip models, human
cell–based models of myocardial inflammation are lacking. Here, we bioengineered a …

Viral infectious diseases remain a global public health problem. The rapid and widespread
spread of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory …

Background Endothelial cell (EC) activation, endotheliitis, vascular permeability, and
thrombosis have been observed in patients with severe coronavirus disease 2019 (COVID …

The ongoing coronavirus disease 2019 (COVID-19) pandemic has boosted the
development of antiviral research. Microfluidic technologies offer powerful platforms for …

Infectious diseases are caused by the invasion of pathogens into a host. To explore the
mechanisms of pathogen infections and cellular responses, human models that can …

Viral and bacterial infections continue to pose significant challenges for numerous
individuals globally. To develop novel therapies to combat infections, more insight into the …