Strategies for the development and approval of COVID-19 vaccines and therapeutics in the post-pandemic period

D Ao, X He, J Liu, L Xu - Signal Transduction and Targeted Therapy, 2023 - nature.com
The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted
in significant casualties and put immense strain on public health systems worldwide, leading …

Simvastatin in critically ill patients with Covid-19

REMAP-CAP Investigators - New England Journal of Medicine, 2023 - Mass Medical Soc
Background The efficacy of simvastatin in critically ill patients with coronavirus disease 2019
(Covid-19) is unclear. Methods In an ongoing international, multifactorial, adaptive platform …

COVID-19 therapeutic potential of natural products

Z Low, R Lani, V Tiong, C Poh, S AbuBakar… - International journal of …, 2023 - mdpi.com
Despite the fact that coronavirus disease 2019 (COVID-19) treatment and management are
now considerably regulated, severe acute respiratory syndrome coronavirus 2 (SARS-CoV …

Antiviral efficacy of molnupiravir versus ritonavir-boosted nirmatrelvir in patients with early symptomatic COVID-19 (PLATCOV): an open-label, phase 2, randomised …

WHK Schilling, P Jittamala, JA Watson… - The Lancet Infectious …, 2024 - thelancet.com
Background Molnupiravir and ritonavir-boosted nirmatrelvir are the two leading oral COVID-
19 antiviral treatments, but their antiviral activities in patients have not been compared …

Early outpatient treatment with remdesivir in patients at high risk for severe COVID-19: a prospective cohort study

S Rajme-López, BA Martinez-Guerra… - Open Forum …, 2022 - academic.oup.com
Background Early treatment of coronavirus disease 2019 (COVID-19) with remdesivir in high-
risk patients, including those with immunosuppression of different causes, has not been …

Utilizing nanozymes for combating COVID-19: advancements in diagnostics, treatments, and preventative measures

J Wang, Q Xie, H Song, X Chen, X Zhang… - Journal of …, 2023 - Springer
The emergence of human severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
poses significant challenges to global public health. Despite the extensive efforts of …

Curtailing virus-induced inflammation in respiratory infections: emerging strategies for therapeutic interventions

AA Globenko, GV Kuzin, AV Rydlovskaya… - Frontiers in …, 2023 - frontiersin.org
Acute respiratory viral infections (ARVI) are the most common illnesses worldwide. In some
instances, mild cases of ARVI progress to hyperinflammatory responses, which are …

Long COVID in low-income and middle-income countries: the hidden public health crisis

W Jassat, LF Reyes, D Munblit, J Caoili, F Bozza… - The Lancet, 2023 - thelancet.com
The COVID-19 pandemic exposed crucial fault lines in society both within and between
different societies. Over the past 3 years, inequity has been highlighted in several areas …

[HTML][HTML] Disparities in COVID-19 Mortality Amongst the Immunosuppressed: A Systematic Review and Meta-analysis for Enhanced Disease Surveillance

M Leston, W Elson, JM Ordóñez-Mena, D Kar… - Journal of Infection, 2024 - Elsevier
Background Effective disease surveillance, including that for COVID-19, is compromised
without a standardised method for categorising the immunosuppressed as a clinical risk …

Early fluvoxamine reduces the risk for clinical deterioration in symptomatic outpatients with Covid-19: a real-world, retrospective, before–after analysis

A Tsiakalos, PD Ziakas, E Polyzou, G Schinas… - Microorganisms, 2023 - mdpi.com
Fluvoxamine, a selective serotonin reuptake inhibitor with anti-inflammatory properties, has
gained attention as a repurposed drug to treat COVID-19. We aimed to explore the potential …