Self-amplifying RNA or RNA replicon is a form of nucleic acid-based vaccine derived from
either positive-strand or negative-strand RNA viruses. The gene sequences encoding …

Liposomes, especially cationic liposomes, are the most common and well-investigated
nanocarriers for biomedical applications, such as drug and gene delivery. Like other types of …

Exploring a plasmid DNA (pDNA)/small interfering RNA (siRNA) delivery vector with
excellent biocompatibility and high gene transfection efficiency still remains a great …

The design of cationic liposomes for efficient mRNA delivery can significantly improve
mRNA-based therapies. Lipoplexes based on polycationic lipid 1, 26-bis (cholest-5-en-3β …

Self-amplifying replicon RNA (RepRNA) possesses high potential for increasing antigen
load within dendritic cells (DCs). The major aim of the present work was to define how …

The ability of immune therapies to control cancer has recently generated intense interest.
This therapeutic outcome is reliant on T cell recognition of tumour cells. The natural function …

Gene silencing through RNA interference (RNAi) is a promising therapeutic approach for a
wide range of disorders, including cancer. Non-viral gene therapy, using specific siRNAs …

Folate receptors (FR) are cellular markers highly expressed in various cancer cells. Here,
we report on the synthesis of a novel folate-containing lipoconjugate (FC) built of 1, 2-di-O …

The mRNA-based vaccine approach is a promising alternative to traditional vaccines due to
its ability for prompt development, high potency, and potential for secure administration and …

Natural lipid molecules are an essential part of life as they constitute the membrane of cells
and organelle. In most of these cases, the hydrophobicity of natural lipids is contributed by …