CircRNAs are a class of single-stranded RNAs with covalently linked head-to-tail topology.
In the decades since its initial discovery, their biogenesis, regulation, and function have …

Trastuzumab notably improves the outcome of human epidermal growth factor receptor 2
(HER2)-positive breast cancer patients, however, resistance to trastuzumab remains a major …

The rapidly expanding field of circular RNA (circ-RNA) research has opened new avenues
in cancer diagnostics and treatment, highlighting the role of serum circRNAs as potential …

Background and aim: As non-coding RNAs, circular RNAs (circRNAs) contribute to the
progression of malignancies by regulating various biological processes. In prostate cancer …

Background Despite aggressive local and regional therapy, triple-negative breast cancer
(TNBC) is characterized by an increased risk of locoregional recurrence. RNA-sequencing …

Abstract Iodine-125 (I-125) radioactive seed implantation is used for the local treatment of
hepatocellular carcinoma (HCC), but the molecular mechanisms regulating its anticancer …

Abstract Background Tyrosine kinase inhibitors (TKIs) are crucial in the targeted treatment of
advanced colorectal cancer (CRC). Anlotinib, a multi-target TKI, has previously been …

Background Refractoriness to surgical resection and chemotherapy makes intrahepatic
cholangiocarcinoma (ICC) a fatal cancer of the digestive system with high mortality and poor …

Circular RNAs (circRNAs) have been implicated in cancer development. However, their
regulation, function, and underlying mechanisms of action remain unclear. We found that …

Circular RNAs (circRNAs) are a unique family of endogenous RNAs devoid of 3′ poly-A
tails and 5′ end caps. These single-stranded circRNAs, found in the cytoplasm, are …