Cancer is an age-related disease, as incidence and mortality for most types of cancer
increase with age. However, how molecular alterations in tumors differ among patients of …

Oxidative stress refers to the imbalance between the production of reactive oxygen species
(ROS) and the endogenous antioxidant defense system. Its involvement in cell senescence …

Cellular senescence is a complex multifactorial biological phenomenon that plays essential
roles in aging, and aging-related diseases. During this process, the senescent cells undergo …

Cancers cause significant mortality and morbidity in adolescents and young adults (AYAs),
but their biological underpinnings are incompletely understood. Here, we analyze clinical …

Purpose: Glioblastoma (GBM) is the most common aggressive primary malignant brain
tumor in adults with a median age of onset of 68 to 70 years old. Although advanced age is …

Introduction Understanding changes in cell identity in cancer and ageing is of great
importance. In this work, we analyzed how gene expression changes in human tissues are …

Gene regulatory networks (GRNs) and gene co-expression networks (GCNs) allow genome-
wide exploration of molecular regulation patterns in health and disease. The standard …

Older patients with cancer, particularly those over 75 years of age, often experience poorer
clinical outcomes compared to younger patients. This can be attributed to age-related …

Aging modifies risk in all cancers, but age is used as a clinical staging criterion uniquely in
thyroid cancer (TC). The molecular drivers of age-dependent TC onset and aggressiveness …

Aging and cancer exhibit apparent links that we will examine in this review. The null
hypothesis that aging and cancer coincide because both are driven by time, irrespective of …