RNA modifications: importance in immune cell biology and related diseases

L Cui, R Ma, J Cai, C Guo, Z Chen, L Yao… - Signal transduction and …, 2022 - nature.com
RNA modifications have become hot topics recently. By influencing RNA processes,
including generation, transportation, function, and metabolization, they act as critical …

N6-methyladenosine (m6A) methylation in kidney diseases: Mechanisms and therapeutic potential

Y Sun, D Jin, Z Zhang, H Ji, X An, Y Zhang… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Abstract The N6-methyladenosine (m6A) modification is regulated by methylases, commonly
referred to as “writers,” and demethylases, known as “erasers,” leading to a dynamic and …

[HTML][HTML] Inhibition of IGF2BP1 attenuates renal injury and inflammation by alleviating m6A modifications and E2F1/MIF pathway

Y Mao, F Jiang, XJ Xu, LB Zhou, R Jin… - … journal of biological …, 2023 - ncbi.nlm.nih.gov
Septic acute kidney injury (AKI) is characterized by inflammation. Pyroptosis often occurs
during AKI and is associated with the development of septic AKI. This study found that …

FBW7/GSK3β mediated degradation of IGF2BP2 inhibits IGF2BP2-SLC7A5 positive feedback loop and radioresistance in lung cancer

Z Zhou, B Zhang, Y Deng, S Deng, J Li, W Wei… - Journal of Experimental …, 2024 - Springer
Background The development of radioresistance seriously hinders the efficacy of
radiotherapy in lung cancer. However, the underlying mechanisms by which radioresistance …

FTO inhibits epithelial ovarian cancer progression by destabilising SNAI1 mRNA through IGF2BP2

M Sun, X Zhang, F Bi, D Wang, X Zhou, X Li, Q Yang - Cancers, 2022 - mdpi.com
Simple Summary Ovarian cancer is the gynaecologic malignant tumour with the highest
mortality. Most patients are already in the advanced stage when they are found, and the 5 …

MrGPS: An m6A-related gene pair signature to predict the prognosis and immunological impact of glioma patients

N Zhang, F Yang, P Zhao, N Jin, H Wu… - Briefings in …, 2024 - academic.oup.com
Abstract N6-methyladenosine (m6A) RNA methylation is the predominant epigenetic
modification for mRNAs that regulates various cancer-related pathways. However, the …

[HTML][HTML] Stabilization of IGF2BP1 by USP10 promotes breast cancer metastasis via CPT1A in an m6A-dependent manner

J Shi, Q Zhang, X Yin, J Ye, S Gao, C Chen… - … journal of biological …, 2023 - ncbi.nlm.nih.gov
Metastasis leads to the vast majority of breast cancer mortality. Increasing evidence has
shown that N6-methyladenosine (m6A) modification and its associated regulators play a …

WTAP activates MAPK signaling through m6A methylation in VEGFA mRNA‐mediated by YTHDC1 to promote colorectal cancer development

M Ye, J Chen, P Yu, C Hu, B Wang, J Bao… - The FASEB …, 2023 - Wiley Online Library
N6‐methyladenosine modification, especially Wilms tumor 1‐associated protein (WTAP), is
reportedly associated with a variety of cancers, including colorectal cancer (CRC) …

METTL14-mediated m6A epitranscriptomic modification contributes to chemotherapy-induced neuropathic pain by stabilizing GluN2A expression via IGF2BP2

W Lu, X Yang, W Zhong, G Chen, X Guo… - The Journal of …, 2024 - Am Soc Clin Investig
Epigenetics is a biological process that modifies and regulates gene expression, affects
neuronal function, and contributes to pain. However, the mechanism by which epigenetics …

Regulation of ULK1 by WTAP/IGF2BP3 axis enhances mitophagy and progression in epithelial ovarian cancer

J Wang, F Zheng, D Wang, Q Yang - Cell Death & Disease, 2024 - nature.com
There is a pressing need for innovative therapeutic strategies for patients with epithelial
ovarian cancer (EOC). Previous studies have shown that UNC-51-like kinase 1 (ULK1), a …