Chronic inflammation is a component of many disease conditions that affect a large group of
individuals worldwide. Chronic inflammation is characterized by persistent, low-grade …

Tumour necrosis factor (TNF) is a classical, pleiotropic pro-inflammatory cytokine. It is also
the first 'adipokine'described to be produced from adipose tissue, regulated in obesity and …

Approximately 6% of adults worldwide have atherosclerosis and thrombosis of the lower
limb arteries (peripheral artery disease (PAD)) and the prevalence is rising. PAD causes leg …

Blood-Brain Barrier (BBB) disruption is an important pathophysiological process of acute
ischemic stroke (AIS), resulting in devastating malignant brain edema and hemorrhagic …

An intense, stereotyped inflammatory response occurs in response to ischaemic and non-
ischaemic injury to the myocardium. The NACHT, LRR and PYD domains-containing protein …

Background The systemic inflammatory response index (SIRI) is a novel inflammatory
biomarker in many diseases. Objectives The aim of this study was to examine the …

Abstract Sodium–glucose cotransporter 2 (SGLT-2) inhibitors (i) reduce cardiovascular and
renal events in patients with and without type 2 diabetes (T2D). However, the underlying …

Cardiovascular disease and cancer are the 2 leading causes of death worldwide. Emerging
evidence suggests common mechanisms between cancer and cardiovascular disease …

Inflammasomes are large protein complexes that play a major role in sensing inflammatory
signals and triggering the innate immune response. Each inflammasome complex has three …

Combining existing drug therapy is essential in developing new therapeutic agents in
disease prevention and treatment. In preclinical investigations, combined effect of certain …