Drug-tolerant persister (DTP) cell populations were originally discovered in antibiotic-
resistant bacterial biofilms. Similar populations with comparable features have since been …

Lung oncogenesis relies on intracellular cysteine to overcome oxidative stress. Several
tumor types, including non-small cell lung cancer (NSCLC), upregulate the system x c …

Reprogramming of methionine metabolism is a conserved hallmark of tumorigenesis.
Recent studies have revealed mechanisms regulating methionine metabolism within the …

Background Although immune checkpoint inhibitor (ICI)-based therapy is advantageous for
patients with advanced melanoma, resistance and relapse are frequent. Thus, it is crucial to …

Triple negative breast cancer (TNBC) presents a formidable challenge due to the lack of
effective treatment modalities. Immunotherapy stands as a promising therapeutic approach; …

Head and neck squamous cell carcinoma (HNSCC) is a formidable cancer type that poses
significant treatment challenges, including radiotherapy (RT) resistance. The metabolic …

The development of resistance by tumor cells to various types of therapy is a significant
problem that decreases the effectiveness of oncology treatments. For more than two …

Gastric cancer is ranked as the fifth most prevalent cancer globally and has long been a
topic of passionate discussion among numerous individuals. However, the incidence of …

Resistance to inactive state-selective RASG12C inhibitors frequently entails accumulation of
RASGTP, rendering effective inhibition of active RAS potentially desirable. Here, we …

Lung cancer is a leading cause of cancer‐related deaths worldwide. Recent studies have
identified pyroptosis, a type of programmed cell death, as a critical process in the …