Trafficking of a single photosensitizing molecule to different intracellular organelles demonstrates effective hydroxyl radical-mediated photodynamic therapy in the …

RC Gilson, R Tang, KS Gautam… - Bioconjugate …, 2019 - ACS Publications
Photodynamic therapy (PDT) is often used in preclinical and clinical treatment regimens.
Reactive oxygen species (ROS) generated by photosensitizers (PSs) upon exposure to light …

Cytotoxic activity of isoniazid derivative in human breast cancer cells

M Barathan, AK Zulpa, KM Vellasamy, V Mariappan… - in vivo, 2021 - iv.iiarjournals.org
Background/Aim: Isoniazid is an antibiotic used for the treatment of tuberculosis. Previously,
we found that the isoniazid derivative (E)-N'-(2, 3, 4-trihydroxybenzylidene) …

Fluorescence lifetime imaging unravels the pathway of glioma cell death upon hypericin-induced photodynamic therapy

M Bassler, J Hiller, F Wackenhut… - 2023 - chemrxiv.org
Malignant primary brain tumors are a group of highly aggressive and often infiltrating tumors
that lack adequate therapeutic treatments to achieve long time survival. Complete tumor …

Potentiation of hypericin-mediated photodynamic therapy cytotoxicity by MK-886: focus on ABC transporters, GDF-15 and redox status

B Kuchárová, J Mikeš, R Jendželovský… - Photodiagnosis and …, 2015 - Elsevier
Background Pretreatment with 5-LOX pathway inhibitor MK-886 potentiates cytotoxic effects
of photodynamic therapy mediated by natural photosensitizer, hypericin. In this study, we …

Evaluation of apoptotic cell death mechanisms induced by hypericin-mediated photodynamic therapy in colon cancer cells

AK SÜLOĞLU, E KARACAOĞLU… - Turkish Journal of …, 2016 - journals.tubitak.gov.tr
Hypericin (HYP)-mediated photodynamic therapy (PDT) is a new alternative treatment
strategy for colon cancer inducing various cell-death pathways. Apoptotic cell death is the …

Potential roles played by IL-6 in hepatitis B infection

M Ebrahim, V Bagheri, MK Arababadi - Future Virology, 2014 - Taylor & Francis
Hepatitis B is a main disorder of the liver, which is induced by HBV. Hepatitis B can induce
liver diseases, such as inflammation, cirrhosis and hepatocellular carcinoma (HCC). Recent …

乌腺金丝桃愈伤组织中总黄酮及金丝桃素含量测定

刘晓丹, 张克勤, 刘连, 李文昌 - 生物技术通报, 2015 - biotech.aiijournal.com
以乌腺金丝桃新鲜叶片为材料, 建立稳定的乌腺金丝桃愈伤组织的培养体系,
进一步对愈伤组织总黄酮与金丝桃素的含量进行测定. 以MS 为基础培养基 …

Growth inhibition effect of HMME-mediated PDT on hepatocellular carcinoma HepG2 cells

L Liu, Y Song, L Ma, L Zang, L Tao, Z Zhang… - Lasers in medical …, 2014 - Springer
Photodynamic therapy (PDT) is considered a promising new strategy for liver cancer
treatment. Three elements of PDT—optical output power, irradiation time, and …

重组人白细胞介素-6 对胶质瘤细胞U87 增生侵袭的影响

刘雅琦, 顾金海, 孟锐, 安芳玲 - 中国老年学杂志, 2015 - cqvip.com
目的探讨重组人白细胞介素(IL)-6 对胶质瘤细胞U87 增生, 侵袭能力的影响及其机制.
方法应用CCK-8 法检测IL-6 对U87 细胞增生的影响并计算增殖率; 应用Transwell 小室检测IL-6 …

[HTML][HTML] Zerumbone mediates apoptosis and induces secretion of proinflammatory cytokines in breast carcinoma cell culture

M Barathan, KM Vellasamy, ZA Ibrahim… - Iranian Journal of …, 2021 - ncbi.nlm.nih.gov
Objective (s): To investigate the potential anti-breast cancer activity of zerumbone in
regulating apoptotic mediators and cytokines in comparison with paclitaxel (positive control) …