The single cell gel electrophoresis or Comet assay is a sensitive, reliable, and rapid method
for DNA double-and single-strand breaks, alkali-labile sites and delayed repair site …

Aberrant oxidative pathways of catecholamine neurotransmitters, ie dopamine and
norepinephrine, are an important biochemical correlate of catecholaminergic neuron loss in …

Recent etiological study in twins (Tanner et al. 1999) strongly suggests that environmental
factors play an important role in typical, non‐familial Parkinson's disease (PD), beginning …

The carrier molecule that transports dopamine (DA) into dopamine neurons by an
electrogenic, Na+-and Cl−-transport-coupled mechanism is known as the dopamine …

Dopamine neurons in the substantia nigra of human brain are selectively vulnerable and the
number decline by aging at 5–10% per decade. Enzymatic and non-enzymatic oxidation of …

An endogenous dopaminergic neurotoxin, N‐methyl (R) salsolinol, was found to induce
apoptosis in human dopaminergic SH‐SY5Y cells by step‐wise activation of apoptotic …

In Parkinson's disease (PD), therapies to delay or suppress the progression of cell death in
nigrostriatal dopamine neurons have been proposed by use of various agents. An inhibitor …

The role of mitochondrial permeability transition (PT) in apoptosis induced by an
endogenous neurotoxin, N‐methyl (R) salsolinol [NM (R) Sal], was studied by use of …

Salsolinol, 1-methyl-6, 7-dihydroxy-1, 2, 3, 4-tetrahydroisoquinoline, is an endogenous
catechol isoquinoline detected in humans by M. Sandler. In human brain, a series of …

Alzheimer's and Parkinson's diseases are the most common neurodegenerative disorders
among the aged. The etiologies of these diseases remain to be clarified, but the common …