Mechanisms, pathophysiology and currently proposed treatments of chronic obstructive pulmonary disease

SO Rodrigues, CMC Cunha, GMV Soares, PL Silva… - Pharmaceuticals, 2021 - mdpi.com
Chronic obstructive pulmonary disease (COPD) is one of the leading global causes of
morbidity and mortality. A hallmark of COPD is progressive airflow obstruction primarily …

RIG-I triggers a signaling-abortive anti-SARS-CoV-2 defense in human lung cells

T Yamada, S Sato, Y Sotoyama, Y Orba, H Sawa… - Nature …, 2021 - nature.com
Efficient immune responses against viral infection are determined by sufficient activation of
nucleic acid sensor–mediated innate immunity,. Coronavirus disease 2019, caused by …

Innate immune recognition against SARS-CoV-2

T Yamada, A Takaoka - Inflammation and Regeneration, 2023 - Springer
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the causative virus of
pandemic acute respiratory disease called coronavirus disease 2019 (COVID-19). Most of …

The establishment of COPD organoids to study host-pathogen interaction reveals enhanced viral fitness of SARS-CoV-2 in bronchi

LLY Chan, DE Anderson, HS Cheng, FX Ivan… - Nature …, 2022 - nature.com
Chronic obstructive pulmonary disease (COPD) is characterised by airflow limitation and
infective exacerbations, however, in-vitro model systems for the study of host-pathogen …

Impact of smoking, COPD and comorbidities on the mortality of COVID-19 patients

D Lacedonia, G Scioscia, C Santomasi, P Fuso… - Scientific Reports, 2021 - nature.com
The prognosis of the coronavirus disease 2019 (COVID-19) patients is variable and
depends on several factors. Current data about the impact of chronic obstructive pulmonary …

Nitric oxide: The missing factor in COVID-19 severity?

A Nikolaidis, R Kramer, S Ostojic - Medical Sciences, 2021 - mdpi.com
Coronavirus disease 2019 (COVID-19) is a contagious respiratory and vascular disease that
continues to spread among people around the world, mutating into new strains with …

Effect of COVID-19-related lockdown οn hospital admissions for asthma and COPD exacerbations: associations with air pollution and patient characteristics

I Sigala, T Giannakas, VG Giannakoulis… - Journal of personalized …, 2021 - mdpi.com
We conducted a retrospective observational study to assess the hospitalization rates for
acute exacerbations of asthma and COPD (chronic obstructive pulmonary disease) during …

Deciphering respiratory-virus-associated interferon signaling in COPD airway epithelium

H Guo-Parke, D Linden, S Weldon, JC Kidney… - Medicina, 2022 - mdpi.com
COPD is a chronic lung disorder characterized by a progressive and irreversible airflow
obstruction, and persistent pulmonary inflammation. It has become a global epidemic …

Goblet cell hyperplasia increases SARS-CoV-2 infection in chronic obstructive pulmonary disease

J Osan, SN Talukdar, F Feldmann… - Microbiology …, 2022 - Am Soc Microbiol
Chronic obstructive pulmonary disease (COPD) is one of the underlying conditions in adults
of any age that place them at risk for developing severe illnesses associated with COVID-19 …

[HTML][HTML] Goblet Cell Hyperplasia Increases SARS-CoV-2 Infection in COPD.

JK Osan, SN Talukdar, F Feldmann, BA DeMontigny… - BioRxiv, 2020 - ncbi.nlm.nih.gov
SARS-CoV-2 has become a major problem across the globe, with approximately 50 million
cases and more than 1 million deaths and currently no approved treatment or vaccine …