Mucosal vaccines—fortifying the frontiers

EC Lavelle, RW Ward - Nature Reviews Immunology, 2022 - nature.com
Mucosal vaccines offer the potential to trigger robust protective immune responses at the
predominant sites of pathogen infection. In principle, the induction of adaptive immunity at …

Coronavirus vaccine development: from SARS and MERS to COVID-19

YD Li, WY Chi, JH Su, L Ferrall, CF Hung… - Journal of biomedical …, 2020 - Springer
Abstract Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a new type of
coronavirus that causes the Coronavirus Disease 2019 (COVID-19), which has been the …

COVID-19 Vaccine: A comprehensive status report

SP Kaur, V Gupta - Virus research, 2020 - Elsevier
The current COVID-19 pandemic has urged the scientific community internationally to find
answers in terms of therapeutics and vaccines to control SARS-CoV-2. Published …

Safety and immunogenicity of a recombinant tandem-repeat dimeric RBD-based protein subunit vaccine (ZF2001) against COVID-19 in adults: two randomised …

S Yang, Y Li, L Dai, J Wang, P He, C Li… - The Lancet Infectious …, 2021 - thelancet.com
Background Although several COVID-19 vaccines have been developed so far, they will not
be sufficient to meet the global demand. Development of a wider range of vaccines, with …

COVID-19 vaccine development and a potential nanomaterial path forward

MD Shin, S Shukla, YH Chung, V Beiss… - Nature …, 2020 - nature.com
The COVID-19 pandemic has infected millions of people with no clear signs of abatement
owing to the high prevalence, long incubation period and lack of established treatments or …

Epidemiology, pathogenesis, clinical presentations, diagnosis and treatment of COVID-19: a review of current evidence

S Rahman, MTV Montero, K Rowe… - Expert review of …, 2021 - Taylor & Francis
Introduction The COVID-19 pandemic has created a public health crisis, infected millions of
people, and caused a significant number of deaths. SARS-CoV-2 transmits from person to …

Overview of immune response during SARS-CoV-2 infection: lessons from the past

VK Shah, P Firmal, A Alam, D Ganguly… - Frontiers in …, 2020 - frontiersin.org
After the 1918 flu pandemic, the world is again facing a similar situation. However, the
advancement in medical science has made it possible to identify that the novel infectious …

[HTML][HTML] Characterization of the receptor-binding domain (RBD) of 2019 novel coronavirus: implication for development of RBD protein as a viral attachment inhibitor …

W Tai, L He, X Zhang, J Pu, D Voronin… - Cellular & molecular …, 2020 - nature.com
Abstract The outbreak of Coronavirus Disease 2019 (COVID-19) has posed a serious threat
to global public health, calling for the development of safe and effective prophylactics and …

The SARS-CoV-2 spike glycoprotein biosynthesis, structure, function, and antigenicity: implications for the design of spike-based vaccine immunogens

L Duan, Q Zheng, H Zhang, Y Niu, Y Lou… - Frontiers in …, 2020 - frontiersin.org
The ongoing pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), poses a grave threat to global public …

Immune response, inflammation, and the clinical spectrum of COVID-19

LF García - Frontiers in immunology, 2020 - frontiersin.org
The current COVID-19 pandemic began in December 2019 in Wuhan (China) and rapidly
extended to become a global sanitary and economic emergency. Its etiological agent is the …