One of the most consistent biological findings in the study of affective disorders is that those
with depression commonly show abnormal cortisol response, which suggests dysregulation …

Objective: Gene–environment (GxE) interactions may comprise an important part of the
aetiology of depression, and childhood maltreatment (CM), a significant stressor, has …

The risk of depression could be evaluated through its multifactorial nature using the
polygenic score (PGS) approach. Assuming a “clinical continuum” hypothesis of mental …

Background Research suggests that genetic variants linked to serotonin functioning
moderate the association between environmental stressors and depressive symptoms, but …

Background Multiple studies of depression indicated a significant role of gene-by-
environment interactions; however, they are mainly limited to the examination of modulating …

Childhood adversity appears to sensitize youth to stress, increasing depression risk
following stressful life events occurring throughout the lifespan. Some evidence suggests …

Genetic variants that regulate hypothalamic–pituitary–adrenal (HPA) axis function have
been demonstrated to moderate the association between parenting and mental health …

Research suggests that genetic variants that regulate the hypothalamic-pituitary-adrenal
(HPA) axis function moderate the association between parenting and anxiety symptoms, but …

Background Despite a growing body of evidence showing both genetic and environmental
influences on adolescent depression and anxiety, the involved comorbid mechanisms …

Research suggests that childhood adversity (CA) is associated with a wide range of
repercussions, including an increased likelihood of interpersonal stress generation. This …