Memory B cell development elicited by mRNA booster vaccinations in the elderly

Z Wang, F Muecksch, R Raspe, F Johannsen… - Journal of Experimental …, 2023 - rupress.org
Despite mRNA vaccination, elderly individuals remain especially vulnerable to severe
consequences of SARS-CoV-2 infection. Here, we compare the memory B cell responses in …

SARS-CoV-2 rebound with and without antivirals

N Petrosillo - The Lancet Infectious Diseases, 2023 - thelancet.com
As the COVID-19 pandemic continues, interventions for preventing SARS-CoV-2
transmission and progression to severe disease remain priorities. Vaccines against COVID …

Too many antibiotics for patients with COVID-19 despite low bacterial infections

DR Giacobbe, M Bassetti - The Lancet Infectious Diseases, 2023 - thelancet.com
Justin Chen and colleagues6 report the results of a noninferiority, pragmatic, cluster-
randomised trial, with randomisation at the bed level, in three hospitals in Edmonton, AB …

[HTML][HTML] COVID-19 symptom-onset to diagnosis and diagnosis to treatment intervals are significant predictors of disease progression and hospitalization in high-risk …

H Shimizu, J Kawase, M Hayashi, K Imaizumi… - Respiratory …, 2023 - Elsevier
Abstract Background Coronavirus disease (COVID-19) is overwhelming healthcare systems
worldwide. This study aimed to elucidate factors that influence disease progression to …

Aesculus hippocastanum extract and the main bioactive constituent β-escin as antivirals agents against coronaviruses, including SARS-CoV-2

FA Peñaranda Figueredo, J Vicente, AA Barquero… - Scientific Reports, 2024 - nature.com
Respiratory viruses can cause life-threatening illnesses. The focus of treatment is on
supportive therapies and direct antivirals. However, antivirals may cause resistance by …

The flavonoid cyanidin shows immunomodulatory and broad-spectrum antiviral properties, including SARS-CoV-2

J Vicente, M Benedetti, P Martelliti, L Vázquez… - Viruses, 2023 - mdpi.com
New antiviral treatments are needed to deal with the unpredictable emergence of viruses.
Furthermore, vaccines and antivirals are only available for just a few viral infections, and …

[HTML][HTML] The importance of increasing primary vaccinations against COVID-19 in Europe

PY Boëlle, E Valdano - Infectious Disease Modelling, 2024 - Elsevier
Abstract In the European Union, mass vaccination against COVID-19 staved off the strict
restrictions that had characterized early epidemic response. Now, vaccination campaigns …

Phase II, Double-Blinded, Randomized, Placebo-Controlled Clinical Trial Investigating the Efficacy of Mebendazole in the Management of Symptomatic COVID-19 …

M El-Tanani, KAA Ahmed, AK Shakya, WG Ammari… - Pharmaceuticals, 2023 - mdpi.com
The outbreak of the COVID-19 pandemic has spread throughout the world, affecting almost
all nations and territories. The current double-blind, randomized, placebo-controlled, phase …

The Additional Value of Lower Respiratory Tract Sampling in the Diagnosis of COVID-19: A Real-Life Observational Study

L Morandi, F Torsani, G Forini, M Tamburrini… - Diagnostics, 2022 - mdpi.com
Background: Since December 2019, SARS-CoV-2 has been causing cases of severe
pneumonia in China and has spread all over the world, putting great pressure on health …

Interleukin-62/lymphocyte as a proposed predictive index for COVID-19 patients treated with monoclonal antibodies

S Rotundo, M Borelli, V Scaglione, R Lionello… - Clinical and …, 2023 - Springer
In a convenience sample of 93 patients treated with monoclonal antibodies (moAbs) against
SARS-CoV-2, the interleukin-62/lymphocyte count ratio (IL-62/LC) was able to predict …