The number of patients with neurodegenerative diseases (NDs) is increasing, along with the
growing number of older adults. This escalation threatens to create a medical and social …

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) constitute
aggressive neurodegenerative pathologies that lead to the progressive degeneration of …

RNA binding proteins fulfil a wide number of roles in gene expression. Multiple mechanisms
of RNA binding protein dysregulation have been implicated in the pathomechanisms of …

Aging is associated with the disruption of protein homeostasis and causally contributes to
multiple diseases, including amyotrophic lateral sclerosis (ALS). One strategy for restoring …

Abstract Aims Mutations in DNA/RNA‐binding factor (fused‐in‐sarcoma) FUS and
superoxide dismutase‐1 (SOD‐1) cause amyotrophic lateral sclerosis (ALS). They were …

Granulovacuolar degeneration (GVD) occurs in Alzheimer's disease (AD) brain due to
compromised autophagy. Endoplasmic reticulum (ER) function and RNA binding protein …

Motoneurons are one of the most energy-demanding cell types and a primary target in
Amyotrophic lateral sclerosis (ALS), a debilitating and lethal neurodegenerative disorder …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that leads
to the death of upper and lower motor neurons. While most cases of ALS are sporadic, some …

The degeneration of motor neurons is a pathological hallmark of motor neuron diseases
(MNDs), but emerging evidence suggests that neuronal vulnerability extends well beyond …

Mutations in RNA binding proteins (RBPs) and in genes regulating autophagy are frequent
causes of familial amyotrophic lateral sclerosis (fALS). The P56S mutation in vesicle …