Diabetic vascular diseases: molecular mechanisms and therapeutic strategies

Y Li, Y Liu, S Liu, M Gao, W Wang, K Chen… - Signal transduction and …, 2023 - nature.com
Vascular complications of diabetes pose a severe threat to human health. Prevention and
treatment protocols based on a single vascular complication are no longer suitable for the …

Metabolic syndrome as a risk factor for Alzheimer's disease: a focus on insulin resistance

A Ezkurdia, MJ Ramírez, M Solas - International Journal of Molecular …, 2023 - mdpi.com
Alzheimer's disease (AD) is the main type of dementia and is a disease with a profound
socioeconomic burden due to the lack of effective treatment. In addition to genetics and …

Advances in research on type 2 diabetes mellitus targets and therapeutic agents

J Su, Y Luo, S Hu, L Tang, S Ouyang - International Journal of Molecular …, 2023 - mdpi.com
Diabetes mellitus is a chronic multifaceted disease with multiple potential complications, the
treatment of which can only delay and prolong the terminal stage of the disease, ie, type 2 …

Unlocking the full potential of SGLT2 inhibitors: expanding applications beyond glycemic control

ME Youssef, G Yahya, MS Popoviciu, S Cavalu… - International Journal of …, 2023 - mdpi.com
The number of diabetic patients has risen dramatically in recent decades, owing mostly to
the rising incidence of type 2 diabetes mellitus (T2DM). Several oral antidiabetic …

Newer glucose‐lowering drugs and risk of dementia: a systematic review and meta‐analysis of observational studies

H Tang, H Shao, CE Shaaban, K Yang… - Journal of the …, 2023 - Wiley Online Library
Background Preclinical studies have suggested potential beneficial effects of newer glucose‐
lowering drugs (GLDs) including dipeptidyl peptidase (DPP)‐4 inhibitors, glucagon‐like …

Diabetes-Alzheimer's connection in older age: SGLT2 inhibitors as promising modulators of disease pathways

F Mancinetti, D Xenos, M De Fano, A Mazzieri… - Ageing Research …, 2023 - Elsevier
Late-onset Alzheimer's disease (LOAD) is the most frequent cause of dementia in older
persons. Subjects affected by type 2 diabetes mellitus (T2DM) are at higher risk of vascular …

Type 2 diabetes mellitus and cognitive function: understanding the connections

L Dao, S Choi, M Freeby - Current Opinion in Endocrinology …, 2023 - journals.lww.com
Type 2 diabetes mellitus and cognitive function: understandi... : Current Opinion in
Endocrinology, Diabetes and Obesity Type 2 diabetes mellitus and cognitive function …

[HTML][HTML] Shared biological mechanisms of depression and obesity: focus on adipokines and lipokines

X Fu, Y Wang, F Zhao, R Cui, W Xie, Q Liu… - Aging (Albany …, 2023 - ncbi.nlm.nih.gov
Depression and obesity are both common disorders currently affecting public health,
frequently occurring simultaneously within individuals, and the relationship between these …

Iron and ferroptosis more than a suspect: beyond the most common mechanisms of neurodegeneration for new therapeutic approaches to cognitive decline and …

M Cerasuolo, I Di Meo, MC Auriemma, F Trojsi… - International Journal of …, 2023 - mdpi.com
Neurodegeneration is a multifactorial process that involves multiple mechanisms. Examples
of neurodegenerative diseases are Parkinson's disease, multiple sclerosis, Alzheimer's …

Association of sodium–glucose cotransporter 2 inhibitors with time to dementia: a population-based cohort study

CY Wu, C Iskander, C Wang, LY Xiong… - Diabetes …, 2023 - Am Diabetes Assoc
OBJECTIVE Type 2 diabetes (T2D) increases dementia risk, but clear evidence to
recommend interventions that can mitigate that risk remains lacking. This population-based …