Since the discovery of electron-wave duality, electron scattering instrumentation has
developed into a powerful array of techniques for revealing the atomic structure of matter …

Cuproptosis, caused by excessively high copper concentrations, is urgently exploited as a
potential cancer therapeutic. However, the mechanisms underlying the initiation …

After fertilization, mouse embryos go through preimplantation development to give rise to
blastocyst. Two key molecular events, zygotic genome activation (ZGA) and the first cell …

During early mammalian embryogenesis, changes in cell growth and proliferation depend
on strict genetic and metabolic instructions. However, our understanding of metabolic …

Generating cells with the molecular and functional properties of embryo cells and with full
developmental potential is an aim with fundamental biological significance. Here we report …

Totipotent cells have the ability to generate embryonic and extra-embryonic tissues.
Interestingly, a rare population of cells with totipotent-like potential, known as 2 cell (2C)-like …

Embryonic genome activation (EGA) is critical for embryonic development. However, our
understanding of the regulatory mechanisms of human EGA is still incomplete. Human …

Dot1l is a histone methyltransferase without a SET domain and is responsible for H3K79
methylation, which marks active transcription. In contradiction, Dot1l also participates in …

Endogenous retroviruses (ERVs) are remnants of ancient parasitic infections and comprise
sizable portions of most genomes. Although epigenetic mechanisms silence most ERVs by …

The process of induced pluripotent stem cells (iPSCs) reprogramming involves several
crucial events, including the mesenchymal-epithelial transition (MET), activation of …