[HTML][HTML] Computational approaches for network-based integrative multi-omics analysis
Advances in omics technologies allow for holistic studies into biological systems. These
studies rely on integrative data analysis techniques to obtain a comprehensive view of the …
studies rely on integrative data analysis techniques to obtain a comprehensive view of the …
[HTML][HTML] Neutrophils and COVID-19: active participants and rational therapeutic targets
J Hazeldine, JM Lord - Frontiers in immunology, 2021 - frontiersin.org
Whilst the majority of individuals infected with severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), the causative pathogen of COVID-19, experience mild to …
coronavirus 2 (SARS-CoV-2), the causative pathogen of COVID-19, experience mild to …
[HTML][HTML] Differential co-expression network analysis reveals key hub-high traffic genes as potential therapeutic targets for COVID-19 pandemic
Background The recent emergence of COVID-19, rapid worldwide spread, and incomplete
knowledge of molecular mechanisms underlying SARS-CoV-2 infection have limited …
knowledge of molecular mechanisms underlying SARS-CoV-2 infection have limited …
[HTML][HTML] Metabolic reprogramming and epigenetic changes of vital organs in SARS-CoV-2–induced systemic toxicity
Extrapulmonary manifestations of COVID-19 are associated with a much higher mortality
rate than pulmonary manifestations. However, little is known about the pathogenesis of …
rate than pulmonary manifestations. However, little is known about the pathogenesis of …
[HTML][HTML] Immunofibrotic drivers of impaired lung function in postacute sequelae of SARS-CoV-2 infection
BACKGROUND Individuals recovering from COVID-19 frequently experience persistent
respiratory ailments, which are key elements of postacute sequelae of SARS-CoV-2 …
respiratory ailments, which are key elements of postacute sequelae of SARS-CoV-2 …
Rapid multi-omics sample preparation for mass spectrometry
Multi-omics analysis is a powerful and increasingly utilized approach to gain insight into
complex biological systems. One major hindrance with multi-omics, however, is the lengthy …
complex biological systems. One major hindrance with multi-omics, however, is the lengthy …
Classical and alternative receptors for SARS‐CoV‐2 therapeutic strategy
Understanding the molecules that are essential for severe acute respiratory syndrome
coronavirus‐2 (SARS‐CoV‐2) entry can provide insights into viral infection and …
coronavirus‐2 (SARS‐CoV‐2) entry can provide insights into viral infection and …
[HTML][HTML] A comprehensive SARS-CoV-2–human protein–protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets
Studying viral–host protein–protein interactions can facilitate the discovery of therapies for
viral infection. We use high-throughput yeast two-hybrid experiments and mass spectrometry …
viral infection. We use high-throughput yeast two-hybrid experiments and mass spectrometry …
Longitudinal plasma proteomics analysis reveals novel candidate biomarkers in acute COVID-19
Y Mohammed, DR Goodlett, MP Cheng… - Journal of proteome …, 2022 - ACS Publications
The host response to COVID-19 pathophysiology over the first few days of infection remains
largely unclear, especially the mechanisms in the blood compartment. We report on a …
largely unclear, especially the mechanisms in the blood compartment. We report on a …
[HTML][HTML] Development and validation of a prognostic COVID-19 severity assessment (COSA) score and machine learning models for patient triage at a tertiary hospital
V Schöning, E Liakoni, C Baumgartner… - Journal of translational …, 2021 - Springer
Background Clinical risk scores and machine learning models based on routine laboratory
values could assist in automated early identification of severe acute respiratory syndrome …
values could assist in automated early identification of severe acute respiratory syndrome …